{{Rsnum
|rsid=4141463
|Gene=MACROD2
|Chromosome=20
|position=14766825
|Orientation=plus
|GMAF=0.3875
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MACROD2
}}[[rs4141463]] is a SNP within an intron of the [[MACROD2]] gene.

A 2010 study by the Autism Genome Project of 1,558 "rigorously defined" [[autism]] spectrum disorder families found some - but slight - evidence for an association between [[rs4141463]] and risk for [[autism]].{{PMID|20663923|OA=1
}}

However, an independent case-control study published in 2011 of 1,170 cases of [[autism]] spectrum disorder patients failed to replicate any association between [[autism]] risk and [[rs4141463]].{{PMID|21656903}} 

{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 28.6 | 54.5 | 17.0
| HCB | 1.5 | 21.2 | 77.4
| JPT | 2.7 | 21.2 | 76.1
| YRI | 10.9 | 46.9 | 42.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 1.5 | 21.2 | 77.4
| CHD | 0.0 | 32.4 | 67.6
| GIH | 19.8 | 46.5 | 33.7
| LWK | 20.0 | 47.3 | 32.7
| MEX | 10.3 | 44.8 | 44.8
| MKK | 19.0 | 46.4 | 34.6
| TSI | 35.6 | 49.5 | 14.9
| HapMapRevision=28
}}

{{PMID Auto
|PMID=22739633
|Title=The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}