{{Rsnum
|rsid=4142041
|Gene=CTNNA3
|Chromosome=10
|position=68640951
|Orientation=plus
|GMAF=0.3453
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 44.1 | 41.4 | 14.4
| HCB | 26.5 | 56.8 | 16.7
| JPT | 27.3 | 48.2 | 24.5
| YRI | 91.1 | 8.2 | 0.7
| ASW | 83.6 | 16.4 | 0.0
| CHB | 26.5 | 56.8 | 16.7
| CHD | 24.5 | 49.1 | 26.4
| GIH | 27.6 | 46.9 | 25.5
| LWK | 85.3 | 14.7 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 63.9 | 35.5 | 0.6
| TSI | 36.0 | 47.0 | 17.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs4142041
|PubMedID=17158188
|Condition=Nicotine dependence
|Gene=CTNNA3
|Risk Allele=G
|pValue=6.00E-006
|OR=1.14
|95CI=0.97-1.35
|OA=1
}}

{{PharmGKB
|RSID=rs4142041
|Name_s=
|Gene_s=CTNNA3
|Feature=
|Evidence=PubMed ID:17158188; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Novel genes identified in a high-density genome wide association study for nicotine dependence (Initial Sample Size: 1,050 cases, 879 controls; Replication Sample Size: NR; Risk Allele: rs4142041-G).
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356598
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18783506
|Title=Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4142041
|overall_frequency_n=53
|overall_frequency_d=128
|overall_frequency=0.414062
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}