{{Rsnum
|rsid=4148356
|Gene=ABCC1
|Chromosome=16
|position=16083418
|Orientation=plus
|GMAF=0.02755
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ABCC1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 5.3 | 94.7
| HCB | 0.7 | 8.8 | 90.4
| JPT | 0.0 | 10.6 | 89.4
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.7 | 8.8 | 90.4
| CHD | 0.0 | 5.5 | 94.5
| GIH | 0.0 | 2.0 | 98.0
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 21.1 | 78.9
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 1.0 | 99.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4148356
|Name_s=Arg723Gln
|Gene_s=ABCC1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:16041243
|Annotation=system: membrane vessicles from HEK cells transfected with WT or variant; FA: variant had approx 50% decrease in transport of tritium labelled 17[beta]-estradiol-17[beta]-D-glucuronide and tritium labelled methotrexate
|Drugs=methotrexate
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165282034
}}

{{PMID Auto
|PMID=16684361
|Title=Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.
|OA=1
}}

{{PMID Auto
|PMID=19214144
|Title=Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population.
|OA=1
}}

{{GET Evidence
|gene=ABCC1
|aa_change=Arg723Gln
|aa_change_short=R723Q
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4148356
|overall_frequency_n=103
|overall_frequency_d=10232
|overall_frequency=0.0100665
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}