{{Rsnum
|rsid=4149584
|Gene=TNFRSF1A
|Chromosome=12
|position=6333477
|Orientation=plus
|GMAF=0.01102
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TNFRSF1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4149584]] is a SNP in the tumor necrosis factor receptor superfamily, member 1A [[TNFRSF1A]] gene.

A large study (~5,000 patients) found two SNPs in the [[TNFRSF1A]] gene that each (independently) increase risk for [[multiple sclerosis]], [[rs1800693]] and [[rs4149584]]. This SNP, [[rs4149584]], was less common but was associated with more risk; the odds ratio is reported as 1.6.{{doi|10.1038/ng.401}}

{{PMID Auto GWAS
|PMID=19525953
|Trait=Multiple sclerosis
|Title=Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|RiskAllele=T
|Pval=0.000005
|OR=1.58
|ORtxt=[1.15-2.17]
|OA=1
}}

{{PMID Auto
|PMID=20430450
|Title=Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain
}}

{{omim
|id=142680
|rsnum=4149584
}}

{{omim
|id=191190
|rsnum=4149584
|variant=0007
}}

{{ClinVar
|rsid=4149584
|Reversed=1
|FwdREF=G
|FwdALT=A,C
|REF=C
|ALT=G,T
|RSPOS=6442643
|CHROM=12
|GMAF=0.011
|dbSNPBuildID=110
|SSR=0
|SAO=1
|VP=0x050368000000140517130101
|GENEINFO=TNFRSF1A:7132
|GENE_NAME=TNFRSF1A
|GENE_ID=7132
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000012.11:g.6442643C>G
|CLNSRC=OMIM Allelic Variant; UnitÃ© mÃ©dicale des maladies autoinflammatoires
|CLNORIGIN=1
|CLNSRCID=191190.0007; 60
|CLNSIG=5
|CLNCUI=C1275126
|CLNDBN=TNF receptor-associated periodic fever syndrome (TRAPS)
|Disease=TNF receptor-associated periodic fever syndrome (TRAPS)
|CLNACC=RCV000013134.21
|Tags=RV;PM;PMC;S3D;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.989; 0.01102
|CLNDSDB=MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1275126:142680:32960:403833009
|COMMON=1
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=11175303
|Title=Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance.
}}

{{PMID Auto
|PMID=23624563
|Title=TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}