{{Rsnum
|rsid=4149601
|Gene=NEDD4L
|Chromosome=18
|position=58149559
|Orientation=plus
|GMAF=0.2925
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NEDD4L
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 50.4 | 38.9
| HCB | 4.4 | 32.1 | 63.5
| JPT | 0.0 | 20.4 | 79.6
| YRI | 15.8 | 46.6 | 37.7
| ASW | 14.0 | 31.6 | 54.4
| CHB | 4.4 | 32.1 | 63.5
| CHD | 1.8 | 33.9 | 64.2
| GIH | 3.0 | 35.6 | 61.4
| LWK | 23.6 | 49.1 | 27.3
| MEX | 6.9 | 15.5 | 77.6
| MKK | 31.2 | 48.1 | 20.8
| TSI | 14.9 | 42.6 | 42.6
| HapMapRevision=28
}}

[[rs4149601]] has been associated with [[hypertension]]. This SNP by itself was associated with diastolic blood pressure (DBP) (p=0.03) and DBP progression over time (p=0.04); in genotypic combination with intronic [[NEDD4L]] SNP [[rs2288774]] it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time.{{PMID|16788695}}

{{PMID Auto
|PMID=21052022
|Title=A functional variant of the NEDD4L gene is associated with beneficial treatment response with ?-blockers and diuretics in hypertensive patients
}}

{{PMID|17487281|OA=1
}} Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.

{{PMID|18268134}} Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.

{{PMID|18293164}} Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.

{{PMID|18591455}} Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.

{{PMID|19156173|OA=1
}} Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population.

{{PMID|19635985}} A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.

{{PMID|20003179|OA=1
}} Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.

{{PMID|20038744}} Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.

{{PMID|21154329}} [Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].

{{PMID Auto
|PMID=23353631
|Title=Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics
|OA=1
}}

{{PMID Auto
|PMID=23549273
|Title=A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}