{{Rsnum
|rsid=4151667
|Gene=CFB
|Chromosome=6
|position=31946247
|Orientation=plus
|GMAF=0.02984
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=CFB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 1.5 | 9.2 | 89.2
| HCB | 0.0 | 8.9 | 91.1
| JPT | 0.0 | 4.5 | 95.5
| YRI | 0.0 | 4.8 | 95.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 8.9 | 91.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[age related macular degeneration]] {{PMID|16518403|OA=1
}}

{{PMID Auto
|PMID=19399715
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain
}}

{{omim
|id=138470
|desc=COMPLEMENT FACTOR B; CFB
|rsnum=4151667
}}
{{PMID Auto
|PMID=19556007
|Title=Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
}}
{{PMID Auto
|PMID=19899988
|Title=Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population
}}

{{omim
|id=138470
|rsnum=4151667
|variant=0003
}}

{{PMID Auto
|PMID=22440158
|Title=CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
}}

{{ClinVar
|rsid=4151667
|Reversed=0
|FwdREF=T
|FwdALT=A
|REF=T
|ALT=A
|RSPOS=31914024
|CHROM=6
|GMAF=0.0298
|dbSNPBuildID=110
|SSR=0
|SAO=1
|VP=0x050068000000150517110101
|GENEINFO=CFB:629
|GENE_NAME=CFB
|GENE_ID=629
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.31914024T>A
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9702; 0.02984
|CLNACC=RCV000017457.24
|CLNDBN=Age-related macular degeneration 14
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=CN180565:615489
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=138470.0003
|COMMON=1
|Disease=Age-related macular degeneration 14
}}

{{PMID Auto
|PMID=17917691
|Title=Genetic markers and biomarkers for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18493315
|Title=C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
|OA=1
}}

{{PMID Auto
|PMID=18806293
|Title=Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD).
}}

{{PMID Auto
|PMID=19187590
|Title=Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population.
}}

{{PMID Auto
|PMID=19259132
|Title=Multilocus analysis of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=20378180
|Title=Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=21609242
|Title=Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.
}}

{{PMID Auto
|PMID=22273503
|Title=Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population.
}}

{{GET Evidence
|gene=CFB
|aa_change=Leu9His
|aa_change_short=L9H
|impact=protective
|qualified_impact=Low clinical importance, Uncertain protective
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4151667
|overall_frequency_n=6
|overall_frequency_d=128
|overall_frequency=0.046875
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|qualityscore_case_control=3
|qualitycomment_case_control=Y
|qualityscore_familial=0
|gene_in_genetests=Y
|in_omim=Y
|pph2_score=0.978
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=6
|autoscore=6
|webscore=Y
|n_web_uneval=8
|variant_evidence=0
|clinical_importance=0
|summary_short=This variant typically occurs along with E318D, forming the H10 haplotype. This variant appears to be protective; it was associated with a significantly lower incidence of age-related macular degeneration in an American study (OR = 0.45).
}}

{{PMID Auto
|PMID=23313922
|Title=Complement gene single nucleotide polymorphisms and biomarker endophenotypes of Alzheimer's disease
}}

{{PMID Auto
|PMID=23233260
|Title=Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}