{{Rsnum
|rsid=419598
|Gene=IL1RN
|Chromosome=2
|position=113129630
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.1846
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL1RN
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 6.2 | 46.9 | 46.9
| HCB | 0.0 | 15.3 | 84.7
| JPT | 0.0 | 14.2 | 85.8
| YRI | 0.0 | 4.1 | 95.9
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.0 | 15.3 | 84.7
| CHD | 2.8 | 13.8 | 83.5
| GIH | 16.8 | 42.6 | 40.6
| LWK | 0.0 | 7.3 | 92.7
| MEX | 10.3 | 53.4 | 36.2
| MKK | 0.0 | 8.3 | 91.7
| TSI | 2.9 | 51.0 | 46.1
| HapMapRevision=28
}}May modulate other variations. Also known as the +2018T/C SNP.

In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the [[rs419598]](C) allele are at 0.29x lower CP risk (p = 0.016).{{PMID|18321309}}

[[IL1B]] -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote {{PMID|11023482}}. SO what's this have to do with [[rs419598]]? Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also [[rs419598(T;T)]], i.e. homozygous for [[IL1RN]] +2018 [[rs419598]] (T) allele (the most common one; also known as "+8006").

{{ neighbor
| rsid = 423904
| distance = 55
}}

{{PMID Auto
|PMID=19733643
|Title=Interleukin-1 region meta-analysis with osteoarthritis phenotypes
}}

{{PMID Auto
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|Title=Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men
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{{PMID Auto
|PMID=20709104
|Title=Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans
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{{PMID|19934104|OA=1
}} Radiographic severity of knee osteoarthritis is conditional on Interleukin 1 Receptor Antagonist gene variations

{{PMID Auto
|PMID=22322675
|Title=IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study.
|OA=1
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
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|Title=Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
|OA=1
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|Title=The different expression patterns of interleukin-1 receptor antagonist in systemic lupus erythematosus.
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{{PMID Auto
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|Title=Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
|OA=1
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{{PMID Auto
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|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
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{{PMID Auto
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|Title=Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.
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{{PMID Auto
|PMID=18615156
|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19043479
|Title=Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=20975573
|Title=Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.
}}

{{PMID Auto
|PMID=21146623
|Title=Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.
}}

{{PMID Auto
|PMID=21279638
|Title=Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.
}}

{{PMID Auto
|PMID=22035161
|Title=Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.
}}

{{PMID Auto
|PMID=23192617
|Title=IL-1RN +2018T&gt;C polymorphism is correlated with colorectal cancer
}}

{{PMID Auto
|PMID=23212299
|Title=Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth
}}

{{PMID Auto
|PMID=23765978
|Title=Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
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{{PMID Auto
|PMID=23602982
|Title=IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort
}}

{{PMID Auto
|PMID=22925444
|Title=Genetic and immunological markers predict titanium implant failure: a retrospective study.
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=24008079
|Title=Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}