{{Rsnum
|rsid=419788
|Gene=SKIV2L
|Chromosome=6
|position=31961022
|Orientation=minus
|GMAF=0.2199
|Gene_s=RDBP,SKIV2L
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 9.7 | 38.1 | 52.2
| HCB | 9.5 | 45.3 | 45.3
| JPT | 14.2 | 47.8 | 38.1
| YRI | 0.7 | 14.3 | 85.0
| ASW | 1.8 | 10.5 | 87.7
| CHB | 9.5 | 45.3 | 45.3
| CHD | 5.5 | 49.5 | 45.0
| GIH | 1.0 | 21.8 | 77.2
| LWK | 0.0 | 8.2 | 91.8
| MEX | 1.7 | 39.7 | 58.6
| MKK | 0.6 | 7.1 | 92.3
| TSI | 2.9 | 26.5 | 70.6
| HapMapRevision=28
}}[[rs419788]], a SNP in an intron of the [[SKIV2L]] gene in the MHC class III region, has been associated with [[lupus]] in a large study of UK patients. In dbSNP orientation, the risk allele is [[rs419788(A)]], and the risk is dose-dependent (i.e. [[rs419788(A;A)]] individuals are at higher risk than [[rs419788(A;G)]] individuals]. The reported odds ratio is 2.0 (CI: 1.6 - 2.6, permuted p < 0.0001). {{PMID|17997607|OA=1
}}

{{PMID Auto
|PMID=19851445
|Title=High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}