{{Rsnum
|rsid=42041
|Gene=CDK6
|Chromosome=7
|position=92617430
|Orientation=plus
|GMAF=0.169
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CDK6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 46.0 | 45.1 | 8.8
| HCB | 90.5 | 9.5 | 0.0
| JPT | 96.5 | 3.5 | 0.0
| YRI | 79.6 | 19.7 | 0.7
| ASW | 70.2 | 29.8 | 0.0
| CHB | 90.5 | 9.5 | 0.0
| CHD | 95.4 | 4.6 | 0.0
| GIH | 79.2 | 20.8 | 0.0
| LWK | 62.7 | 35.5 | 1.8
| MEX | 63.8 | 34.5 | 1.7
| MKK | 67.9 | 31.4 | 0.6
| TSI | 52.9 | 42.2 | 4.9
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs42041
|PubMedID=18794853
|Condition=Rheumatoid arthritis
|Gene=CDK6
|Risk Allele=G
|pValue=4.00E-006
|OR=1.11
|95CI=
|OA=1
}}

{{PMID Auto
|PMID=19644859
|Title=Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis
|OA=1
}}

{{PharmGKB
|RSID=rs42041
|Name_s=
|Gene_s=CDK6
|Feature=
|Evidence=PubMed ID:18794853; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Common variants at CD40 and other loci confer risk of rheumatoid arthritis (Initial Sample Size: 3,393 cases, 12,460 controls; Replication Sample Size: 3,929 cases, 5,807 controls; Risk Allele: rs42041-G). This variant is associated with Rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356419
}}
{{PMID Auto
|PMID=20049410
|Title=A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis
}}

{{PMID|19435719|OA=1
}} Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.

{{PMID|19674979|OA=1
}} Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

{{PMID|20439292}} Genetic variants in the prediction of rheumatoid arthritis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs42041
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{PMID Auto
|PMID=25138370
|Title=Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}