{{Rsnum
|rsid=4220
|Gene=FGB
|Chromosome=4
|position=154570607
|Orientation=plus
|GMAF=0.1726
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FGB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.6 | 31.2 | 65.2
| HCB | 3.7 | 34.1 | 62.2
| JPT | 0.9 | 25.9 | 73.2
| YRI | 2.1 | 18.8 | 79.2
| ASW | 0.0 | 8.8 | 91.2
| CHB | 3.7 | 34.1 | 62.2
| CHD | 6.5 | 41.7 | 51.9
| GIH | 5.0 | 30.7 | 64.4
| LWK | 0.0 | 17.4 | 82.6
| MEX | 6.9 | 34.5 | 58.6
| MKK | 1.3 | 12.3 | 86.5
| TSI | 5.0 | 29.7 | 65.3
| HapMapRevision=28
}}{{PMID Auto
|PMID=20135074
|Title=A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
}}

{{PMID Auto
|PMID=20167083
|Title=Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study
|OA=1
}}

{{omim
|id=134830
|rsnum=4220
|variant=0004
}}

{{ClinVar
|rsid=4220
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=155491759
|CHROM=4
|GMAF=0.1731
|dbSNPBuildID=36
|SSR=0
|SAO=1
|VP=0x05037800000015051f110100
|GENEINFO=FGB:2244
|GENE_NAME=FGB
|GENE_ID=2244
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000004.11:g.155491759G>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8274; 0.1726
|CLNACC=RCV000017808.1
|CLNDBN=FIBRINOGEN BALTIMORE 2
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=134830.0004
|COMMON=1
|Disease=FIBRINOGEN BALTIMORE 2
}}

{{PMID Auto
|PMID=19064790
|Title=Predictive genomics of cardioembolic stroke.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20388367
|Title=[Polymorphisms of vascular diseases-related genes in Guangzhou Biobank Cohort Study].
}}

{{PMID Auto
|PMID=21258858
|Title=Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts.
}}

{{PMID Auto
|PMID=22116284
|Title=A two-step genetic study on quantitative precursors of coronary artery disease in a homogeneous Indian population: case-control association discovery and validation by transmission-disequilibrium test.
}}

{{PMID Auto
|PMID=22273812
|Title=Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey.
|OA=1
}}

{{GET Evidence
|gene=FGB
|aa_change=Arg419Lys
|aa_change_short=R419K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4220
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-3
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23220916
|Title=Elevated fibrinogen levels are associated with risk of pulmonary embolism, but not with deep venous thrombosis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}