{{Rsnum
|rsid=42490
|Gene=RIPK2
|Chromosome=8
|position=89766285
|Orientation=plus
|GMAF=0.4343
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RIPK2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 35.4 | 45.1 | 19.5
| HCB | 22.8 | 49.3 | 27.9
| JPT | 18.8 | 42.0 | 39.3
| YRI | 49.3 | 42.5 | 8.2
| ASW | 37.5 | 46.4 | 16.1
| CHB | 22.8 | 49.3 | 27.9
| CHD | 19.4 | 50.0 | 30.6
| GIH | 19.8 | 43.6 | 36.6
| LWK | 63.6 | 29.1 | 7.3
| MEX | 19.0 | 55.2 | 25.9
| MKK | 51.9 | 44.2 | 3.9
| TSI | 39.6 | 43.6 | 16.8
| HapMapRevision=28
}}Variant in the [[RIPK2]] gene associated with a reduced risk of [[leprosy]] in Asians, according to the [http://blog.23andme.com/2009/12/16/snpwatch-genetic-association-study-of-leprosy-yields-new-insights-into-an-ancient-disease/ 23andMe blog]. The protective allele is A, and the odds ratio is 0.76.

{{PMID Auto GWAS
|PMID=20018961
|Trait=Leprosy
|Title=Genomewide Association Study of Leprosy
|RiskAllele=G
|Pval=1E-16
|OR=1.32
|ORtxt=[1.23-1.41]
}}

{{PMID Auto
|PMID=22504414
|Title=Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs42490
|overall_frequency_n=69
|overall_frequency_d=126
|overall_frequency=0.547619
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=61
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

[[Leprosy Susceptibility]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}