{{Rsnum
|rsid=4276227
|Gene=CMTM8
|Chromosome=3
|position=32289194
|Orientation=plus
|GMAF=0.3191
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CMTM8
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 42.5 | 50.4 | 7.1
| HCB | 75.9 | 21.9 | 2.2
| JPT | 92.9 | 7.1 | 0.0
| YRI | 37.4 | 45.6 | 17.0
| ASW | 42.1 | 47.4 | 10.5
| CHB | 75.9 | 21.9 | 2.2
| CHD | 74.3 | 25.7 | 0.0
| GIH | 65.3 | 28.7 | 5.9
| LWK | 36.4 | 43.6 | 20.0
| MEX | 15.5 | 44.8 | 39.7
| MKK | 44.9 | 44.9 | 10.3
| TSI | 44.1 | 49.0 | 6.9
| HapMapRevision=28
}}
[[rs4276227]] has been reported in a large study to be associated with [[bipolar disorder]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.2 (CI 0.99-1.46), and for homozygotes, 1.49 (CI 1.23-1.81). {{PMID|17554300|OA=1
}}

{{PMID Auto
|PMID=19308021
|Title=Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}