{{Rsnum
|rsid=4290270
|Gene=TPH2
|Chromosome=12
|position=72022455
|Orientation=plus
|ReferenceAllele=A
|GMAF=0.4949
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=TPH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 10.8 | 35.4 | 53.8
| HCB | 22.2 | 57.8 | 20.0
| JPT | 13.3 | 55.6 | 31.1
| YRI | 34.9 | 47.6 | 17.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 57.8 | 20.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}Only for Hispanics, individuals who have a genoset composed of [[rs1799913]](C;C) and [[rs4290270]](T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012).{{PMID|18181017}}

{{PMID Auto
|PMID=19352219
|Title=Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder
}}
{{PMID Auto
|PMID=19763617
|Title=Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease
}}

{{PMID Auto
|PMID=21620479
|Title=Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population
}}

{{PMID Auto
|PMID=17167340
|Title=Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees.
}}

{{PMID Auto
|PMID=17453063
|Title=Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.
}}

{{PMID Auto
|PMID=18698231
|Title=Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=20126463
|Title=Alternative splicing and extensive RNA editing of human TPH2 transcripts.
|OA=1
}}

{{PMID Auto
|PMID=20938755
|Title=Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21937687
|Title=Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
}}

{{PMID Auto
|PMID=22655589
|Title=Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
}}

{{PMID Auto
|PMID=23628433
|Title=Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}