{{Rsnum
|rsid=4307059
|Chromosome=5
|position=25967594
|Orientation=plus
|GMAF=0.2365
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.4 | 49.6 | 38.1
| HCB | 2.9 | 23.5 | 73.5
| JPT | 0.9 | 26.5 | 72.6
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 10.5 | 89.5
| CHB | 2.9 | 23.5 | 73.5
| CHD | 0.9 | 25.7 | 73.4
| GIH | 16.8 | 46.5 | 36.6
| LWK | 0.0 | 0.9 | 99.1
| MEX | 10.5 | 31.6 | 57.9
| MKK | 2.6 | 25.6 | 71.8
| TSI | 15.8 | 50.5 | 33.7
| HapMapRevision=28
}}[http://blog.23andme.com/2009/04/28/snpwatch-connections-between-brain-cells-may-be-key-to-autism-puzzle/ 23andMe blog] [[rs4307059]] — compared to two copies of a C, each copy of the more common T version increased the odds of [[autism]] by 1.19 times. [http://dx.doi.org/10.1038/nature07999]

{{PMID Auto
|PMID=19404256
|Title=Common genetic variants on 5p14.1 associate with autism spectrum disorders
|OA=1
}}

{{PharmGKB
|RSID=rs4307059
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19404256
|Annotation=This SNP on 5p14.1 was associated with autism spectrum disorder in a combined analysis of four GWAS data sets with a total of more than 10,000 subjects of European ancestry. This SNP is in an intergenic region between CDH10 and CDH9 that contains several highly conserved genomic elements.
|Drugs=
|Drug Classes=
|Diseases=Autism Spectrum Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA164741095
}}

{{PMID Auto
|PMID=20634369
|Title=Association Between a High-Risk Autism Locus on 5p14 and Social Communication Spectrum Phenotypes in the General Population
|OA=1
}}
{{PMID Auto
|PMID=22491950
|Title=A noncoding RNA antisense to moesin at 5p14.1 in autism
}}

{{omim
|id=209850
|rsnum=4307059
}}

{{PMID Auto
|PMID=19456320
|Title=A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.
|OA=1
}}

{{PMID Auto
|PMID=19812673
|Title=A genome-wide linkage and association scan reveals novel loci for autism.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4307059
|overall_frequency_n=29
|overall_frequency_d=128
|overall_frequency=0.226562
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22739633
|Title=The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families
}}

{{PMID Auto
|PMID=22846907
|Title=Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}