{{Rsnum
|rsid=4324715
|Chromosome=5
|position=142289942
|Orientation=plus
|GMAF=0.3549
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 39.8 | 42.5 | 17.7
| HCB | 59.1 | 36.5 | 4.4
| JPT | 52.2 | 38.9 | 8.8
| YRI | 65.3 | 30.6 | 4.1
| ASW | 52.6 | 40.4 | 7.0
| CHB | 59.1 | 36.5 | 4.4
| CHD | 52.3 | 42.2 | 5.5
| GIH | 20.8 | 50.5 | 28.7
| LWK | 72.7 | 24.5 | 2.7
| MEX | 32.8 | 39.7 | 27.6
| MKK | 55.8 | 42.9 | 1.3
| TSI | 19.6 | 50.0 | 30.4
| HapMapRevision=28
}}Testicular germ cell tumor risk I("TGCT"; i.e. [[testicular cancer]] risk) was increased 40% per copy of the major (T) allele at [[rs4324715]] and [[rs6897876]] (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 [[SPRY4]] gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [doi|10.1038/ng.393]

{{PMID Auto
|PMID=19483682
|Title=Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
|OA=1
}}

{{PMID Auto
|PMID=22072546
|Title=Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}