{{Rsnum
|rsid=4351
|Gene=ACE
|Chromosome=17
|position=63492371
|Orientation=plus
|GMAF=0.4651
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ACE
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 30.8 | 40.0 | 29.2
| HCB | 48.9 | 46.7 | 4.4
| JPT | 17.8 | 66.7 | 15.6
| YRI | 37.1 | 50.0 | 12.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 48.9 | 46.7 | 4.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4351
|Name_s=
|Gene_s=ACE
|Feature=Intron
|Evidence=PubMed ID:16642441
|Annotation=In an inbred Israeli Arab population, rs4351 was shown to be significantly associated with risk of developing Alzheimer Disease, especially when analyzed in a combined haplotype with rs4343.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161795941
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=21960125
|Title=Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4351
|overall_frequency_n=64
|overall_frequency_d=128
|overall_frequency=0.5
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23281178
  |Trait=Metabolite levels
  |Title=A genome-wide assessment of variability in human serum metabolism.
  |RiskAllele=A
  |Pval=9E-13
  |OR=NR
  |ORtxt=NR
  }}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}