{{Rsnum
|rsid=4355801
|Chromosome=8
|position=118911634
|Orientation=plus
|GMAF=0.3039
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Increased risk with A allele
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 28.6 | 55.4 | 16.1
| HCB | 43.7 | 49.6 | 6.7
| JPT | 46.9 | 46.0 | 7.1
| YRI | 98.0 | 2.0 | 0.0
| ASW | 71.9 | 26.3 | 1.8
| CHB | 43.7 | 49.6 | 6.7
| CHD | 59.6 | 35.8 | 4.6
| GIH | 45.5 | 41.6 | 12.9
| LWK | 90.0 | 10.0 | 0.0
| MEX | 24.1 | 50.0 | 25.9
| MKK | 82.7 | 16.7 | 0.6
| TSI | 46.1 | 40.2 | 13.7
| HapMapRevision=28
}}[http://www.medpagetoday.com/Endocrinology/Osteoporosis/tb/9271 news] rs4355801, was associated with a 20% increased risk of osteoporosis (significant at P=0.038). 

At least one copy of the risk allele (A) of rs4355801 was found in 79% of study participants.

Participants carrying at least one copy of each risk allele -- 22% of the study population -- had a 50% increased risk of osteoporosis, which was significant at P=0.0026, and a 29% increased risk of osteoporotic fractures (significant at P=0.014).

{{PMID|18455228|OA=1
}} [[rs3736228]] associated with decreased bone mineral density (p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). 

[[rs4355801]] associated with decreased bone mineral density (p=7.6x10(-10) for lumbar spine and p=3.3x10(-8) for femoral neck) and increased risk of osteoporosis (OR 1.2, 95% CI 1.01-1.42, p=0.038). 

The presence of both risk alleles increased the risk of osteoporotic fractures (OR 1.3, 1.08-1.63, p=0.006) and this effect was independent of bone mineral density

{{GWAS Summary
|SNP=rs4355801
|PubMedID=18455228
|Condition=Bone mineral density
|Gene=TNFRSF11B
|Risk Allele=A
|pValue=8.00E-010
|OR=0.09
|95CI=NR) SD decreas
|OA=1
}}

{{PharmGKB
|RSID=rs4355801
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18455228; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study (Initial Sample Size: 2,094 women; Replication Sample Size: 6,463 individuals; Risk Allele: rs4355801-A). This variant is associated with Bone mineral density.
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356408
}}

{{PMID Auto
|PMID=20146170
|Title=Association of LPR5 Polymorphism with Bone Mass Density and Cholesterol Level in Population of Chinese Han
}}

{{PMID Auto
|PMID=20960157
|Title=A polymorphism near osteoprotegerin gene confer risk of obesity in Uyghurs
}}

{{PharmGKB
|RSID=rs4355801
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18455228
|Annotation=This variant is associated with decreased bone mineral density and an increased risk of osteoporosis. Individuals with risk allele at rs4355801 have reduced expression of TNFRSF11B in lymphoblast cell lines.
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases, Metabolic; Bone Resorption; Fractures, Bone; Osteoporosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162316735
}}

{{PMID Auto
|PMID=22079369
|Title=TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=19629617
|Title=Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
|OA=1
}}

{{PMID Auto
|PMID=20072603
|Title=Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
|OA=1
}}

{{PMID Auto
|PMID=20534768
|Title=OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4355801
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24130145
|Title=Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women
}}

{{PMID Auto
|PMID=23531404
|Title=Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}