{{Rsnum
|rsid=4363657
|Gene=SLCO1B1
|Chromosome=12
|position=21215788
|Orientation=plus
|GMAF=0.2484
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLCO1B1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.9 | 31.0 | 68.1
| HCB | 23.0 | 44.4 | 32.6
| JPT | 17.7 | 43.4 | 38.9
| YRI | 1.4 | 24.5 | 74.1
| ASW | 5.3 | 31.6 | 63.2
| CHB | 23.0 | 44.4 | 32.6
| CHD | 27.8 | 40.7 | 31.5
| GIH | 0.0 | 12.9 | 87.1
| LWK | 1.8 | 26.6 | 71.6
| MEX | 1.8 | 17.5 | 80.7
| MKK | 4.5 | 27.6 | 67.9
| TSI | 3.9 | 37.3 | 58.8
| HapMapRevision=28
}}
[[rs4363657]] is a SNP in the [[SLCO1B1]] gene, a gene which encodes a protein involved in the liver's uptake of certain drugs, including the [[statins]] used to lower cholesterol levels.

{{PMID|18650507}}  [[rs4363657]] in nearly complete linkage disequilibrium with [[rs4149056]] SNP (r<sup>2</sup>=0.97), which has been linked to statin metabolism. rs4149056(C) odds ratio for myopathy among 20,000 individuals taking either 40 or 80mg of [[simvastatin]] daily was 4.5 (CI: 2.6-7.7) per copy of the C allele, and 16.9 (CI: 4.7-61.1) in (C;C) as compared with (T;T) homozygotes.

See also [[rs4149056]] for a more detailed description of the effect of [[SLCO1B1]] gene SNPs on the metabolism of many drugs.

{{PMID|23942138|OA=1
}} SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink

{{omim
|desc=SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B1; SLCO1B1
|id=604843
|rsnum=4363657
}}

{{PharmGKB
|RSID=rs4363657
|Name_s=
|Gene_s=SLCO1B1
|Feature=
|Evidence=PubMed ID:18650507
|Annotation=This SNP located within SLCO1B1 on chromosome 12 yielded a single strong association of myopathy in a genomewide scan.
|Drugs=
|Drug Classes=HMG COA REDUCTASE INHIBITORS
|Diseases=Muscular Diseases; Myopathy, Central Core
|Curation Level=Curated
|PharmGKB Accession ID=PA162356045
}}

{{PMID Auto
|PMID=21646302
|Title=Mayo Genome Consortia: A Genotype-Phenotype Resource for Genome-Wide Association Studies With an Application to the Analysis of Circulating Bilirubin Levels
|OA=1
}}

{{PMID Auto
|PMID=21992719
|Title=SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group
|OA=1
}}

{{PMID Auto
|PMID=19414484
|Title=Genome-wide association meta-analysis for total serum bilirubin levels.
|OA=1
}}

{{PMID Auto
|PMID=19460916
|Title=Genetic architecture of type 2 diabetes: recent progress and clinical implications.
|OA=1
}}

{{PMID Auto
|PMID=22582980
|Title=Genetic predisposition to atorvastatin-induced myopathy: a case report.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4363657
|overall_frequency_n=23
|overall_frequency_d=128
|overall_frequency=0.179688
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23708174
|Title=Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}