{{Rsnum
|rsid=439401
|Gene=APOE
|Chromosome=19
|position=44911194
|Orientation=plus
|GMAF=0.3944
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 40.2 | 44.6 | 15.2
| HCB | 16.1 | 53.3 | 30.7
| JPT | 15.0 | 42.5 | 42.5
| YRI | 80.3 | 18.4 | 1.4
| ASW | 70.2 | 29.8 | 0.0
| CHB | 16.1 | 53.3 | 30.7
| CHD | 16.5 | 52.3 | 31.2
| GIH | 18.8 | 49.5 | 31.7
| LWK | 71.8 | 24.5 | 3.6
| MEX | 24.1 | 60.3 | 15.5
| MKK | 44.2 | 47.4 | 8.4
| TSI | 33.7 | 47.5 | 18.8
| HapMapRevision=28
}}

This appears to be the snp on the Illumina Human 550 which is closest to [[rs4420638]]

{{PMID Auto GWAS
|PMID=19060911
|Trait=Triglycerides
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=2E-9
|OR=0.09
|ORtxt=[NR] SD increase
|OA=1
}}

{{PharmGKB
|RSID=rs439401
|Name_s=
|Gene_s=APOE, APOC1
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,815 individuals; Replication Sample Size: NR); (Region: 19q13.32; Reported Gene(s): TOMM40, APOE; Risk Allele: rs439401-G); (p-value= 0.000000002).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740230
}}

{{PMID Auto GWAS
|PMID=21123754
|Trait=None
|Title=Genome-wide association study of CSF biomarkers A{beta}1-42, t-tau, and p-tau181p in the ADNI cohort.
|RiskAllele=
|Pval=0.000001
|OR=None
|ORtxt=None
|OA=1
}}
{{PMID Auto GWAS
|PMID=21386085
|Trait=None
|Title=A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
|RiskAllele=C
|Pval=1E-8
|OR=0.2400
|ORtxt=[0.16-0.32] unit increase
|OA=1
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=1E-30
|OR=5.5000
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22419519
|Title=Impact of the Reelin signaling cascade (Ligands-Receptors-Adaptor Complex) on cognition in schizophrenia.
}}

{{PMID Auto
|PMID=18254975
|Title=Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
|OA=1
}}

{{PMID Auto
|PMID=18682748
|Title=Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=18823527
|Title=A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
|OA=1
}}

{{PMID Auto
|PMID=19118814
|Title=Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=19299407
|Title=Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=19327864
|Title=SNPit: a federated data integration system for the purpose of functional SNP annotation.
|OA=1
}}

{{PMID Auto
|PMID=19541455
|Title=Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.
}}

{{PMID Auto
|PMID=19668339
|Title=Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=19936222
|Title=Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
|OA=1
}}

{{PMID Auto
|PMID=20070850
|Title=Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
|OA=1
}}

{{PMID Auto
|PMID=20467002
|Title=Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.
|OA=1
}}

{{PMID Auto
|PMID=21283811
|Title=Associations between APOE variants and metabolic traits and the impact of psychological stress.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs439401
|overall_frequency_n=82
|overall_frequency_d=126
|overall_frequency=0.650794
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23435269
|Title=Chronic Family Stress Moderates the Association between a TOMM40 Variant and Triglyceride Levels in Two Independent Caucasian Samples
|OA=1
}}

{{PMID Auto
|PMID=24160669
|Title=Impact of APOE gene polymorphisms on the lipid profile in an Algerian population
}}

{{PMID Auto
|PMID=22430674
|Title=Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}