{{Rsnum
|rsid=440446
|Gene=APOE
|Chromosome=19
|position=44905910
|Orientation=plus
|GMAF=0.3838
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=APOE
}}[[rs440446]] is a SNP in an intron of the apolipoprotein E [[APOE]] gene; it is also known as the IVS1+69 variant.

In a study of ~1,000 Chinese patients with various biliary tract conditions, including cancer and gallstones, men carrying a [[rs440446]](C) allele (in dbSNP orientation) had a 1.7x risk of [[gallstone disease]] [CI: 1.2-2.4], a 1.8x risk of [[gallbladder cancer]] (CI: 1.0-3.3), a 3.7x risk of [[bile duct cancer]] (CI: 2.0-7.0), and a 4x risk of ampullary cancer (CI: 1.4-12.4).{{PMID|18296645|OA=1
}}

Note: orientation relative to dbSNP entry is reversed as published.

{{ neighbor
| rsid = 405509
| distance = 331
}}

{{PMID Auto
|PMID=19888660
|Title=Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China
|OA=1
}}

{{PMID Auto
|PMID=21266206
|Title=Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - The Cardiovascular Risk in Young Finns Study
}}

{{PMID Auto
|PMID=22028770
|Title=APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
|OA=1
}}

{{PMID|15113403|OA=1
}} Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.

{{PMID|15157284|OA=1
}} Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.

{{PMID|17672902|OA=1
}} Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.

{{PMID|18076107|OA=1
}} Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.

{{PMID|18813964|OA=1
}} Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

{{PMID|18974842|OA=1
}} Gender differences in genetic risk profiles for cardiovascular disease.

{{PMID|19058936|OA=1
}} A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females.

{{PMID|20546958}} Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females.

{{PMID|20663622}} A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India.

{{PMID|20723945}} The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.

{{PMID Auto
|PMID=25085564
|Title=Influence of multiple
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}