{{Rsnum
|rsid=4415084
|Chromosome=5
|position=44662413
|Orientation=plus
|GMAF=0.4871
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 38.1 | 48.7 | 13.3
| HCB | 29.9 | 40.1 | 29.9
| JPT | 18.6 | 54.0 | 27.4
| YRI | 11.6 | 43.8 | 44.5
| ASW | 10.5 | 43.9 | 45.6
| CHB | 29.9 | 40.1 | 29.9
| CHD | 17.6 | 54.6 | 27.8
| GIH | 23.8 | 49.5 | 26.7
| LWK | 14.5 | 45.5 | 40.0
| MEX | 28.1 | 45.6 | 26.3
| MKK | 11.5 | 46.2 | 42.3
| TSI | 31.4 | 49.0 | 19.6
| HapMapRevision=28
}}
[[rs4415084]] and [[rs10941679]] confer risk for estrogen receptor [[breast cancer]] (ER)-positive tumors (OR = 1.27, P = 2.5E-12 for rs10941679) based on a study of 6,145 cases. {{PMID|18438407}} From a DeCode user report, the risk allele appears to be T; this T;T individual reportedly has a 1.19x increased risk of [[breast cancer]]. 

{{omim
|desc=BREAST CANCER
|id=114480
|rsnum=4415084
}}

{{PharmGKB
|RSID=rs4415084
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18438407
|Annotation=This variant is associated with risk for estrogen receptor (ER)-positive breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162355813
}}

{{PMID Auto
|PMID=20095854
|Title=Novel Breast Cancer Risk Alleles and Interaction with Ionizing Radiation among U.S. Radiologic Technologists
|OA=1
}}

{{PMID Auto
|PMID=20140701
|Title=Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
|OA=1
}}

{{PMID Auto GWAS
|PMID=21263130
|Trait=None
|Title=Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study
|RiskAllele=T
|Pval=8E-11
|OR=1.1700
|ORtxt=[1.11-1.22]
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=22832384
|Title=Genetic variants at 5p12 and risk of breast cancer in Han Chinese
}}
the two risk SNPs reported in the European population were neither associated with breast cancer risk in our Chinese population

{{PMID|19330030|OA=1
}} A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

{{PMID|20085711|OA=1
}} Leveraging genetic variability across populations for the identification of causal variants.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4415084
|overall_frequency_n=71
|overall_frequency_d=128
|overall_frequency=0.554688
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22965832
|Title=Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.
}}

{{PMID Auto
|PMID=25002657
|Title=Breast cancer susceptibility variants and mammographic density phenotypes in Norwegian postmenopausal women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}