{{Rsnum
|rsid=4444903
|Gene=EGF
|Chromosome=4
|position=109912954
|Orientation=plus
|GMAF=0.4183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=EGF
}}[[rs4444903]] is a SNP, also known as +61, located in the promoter region of the epidermal growth factor [[EGF]] gene that influences the amount of EGF produced. The [[rs4444903]](G) allele appears to produce higher amounts of EGF than the (A) allele.

A study of 2 Caucasian populations of patients with alcoholic cirrhosis indicates that, for these patients, the presence of the risk allele [[rs4444903(G)]] increases the chances of developing hepatocellular carcinoma ([[liver cancer]]). After adjusting for age, sex, race, etiology, and severity of cirrhosis the number of (G) copies led to an odds ratio for either (G;G) or (A;G) genotypes versus the (A;A) genotype of 3.49 (CI: 1.29-9.44, p=.01). {{PMID|18167406}}

In another study, analysis of 197 glioma patients showed that the [[rs4444903]](G) allele conferred higher risks for gliomas (odds ratio 1.32, CI: 1.04-1.67), glioblastomas (OR, 1.47, CI: 1.02-2.10), and oligodendrogliomas (OR, 1.55, CI: 1.07-2.23). In general, the risk was about the same for a carrier or one or two (G) alleles, however, no significant association was observed with patients' overall survival.{{PMID|17473192}}

A study of 126 Indian [[gallbladder cancer]] patients concluded that the [[rs4444903]](G;G) genotype was at increased risk, but only in females (odds ratio 3.45, CI: 1.52-7.82, p = 0.003).{{PMID|18571008}}

effects lots of no known risk
pmids15373782 15729146 16214932 16214933 16214934 16214935 16217151 16217152 16217153

{{PMID|19010984|OA=1
}} [[rs4444903]], [[rs2298991]], [[rs7692976]] and [[rs4533485]] significantly interacted with gender for acute respiratory distress syndrome  risk.

[[popular in pubmed]]

{{PMID Auto
|PMID=19319135
|Title=Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival.
|OA=1
}}

{{omim
|desc=HEPATOCELLULAR CARCINOMA
|id=114550
|rsnum=4444903
}}

{{omim
|desc=EPIDERMAL GROWTH FACTOR; EGF
|id=131530
|rsnum=4444903
}}

{{PMID Auto
|PMID=20487573
|Title=Association between EGF +61 G/A and glioma risk in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=21567271
|Title=Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population
}}

{{PMID Auto
|PMID=22122913
|Title=Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C
}}

{{PMID Auto
|PMID=22829952
|Title=A Functional +61G/A Polymorphism in Epidermal Growth Factor Is Associated with Glioma Risk among Asians
|OA=1
}}

{{PMID|15663953}} Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population.

{{PMID|17204151|OA=1
}} VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

{{PMID|18676680|OA=1
}} Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

{{PMID|19372140|OA=1
}} EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

{{PMID|19379518|OA=1
}} Development of a fingerprinting panel using medically relevant polymorphisms.

{{PMID|19822020|OA=1
}} Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

{{PMID|20203692}} A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population.

{{PMID|21440548|OA=1
}} A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.

{{PMID|22236006|OA=1
}} Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.

{{PMID Auto
|PMID=23403233
|Title=EGF +61A&gt;G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis
}}

{{PMID Auto
|PMID=24363559
|Title=A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients
|OA=1
}}

{{PMID Auto
|PMID=22848662
|Title=Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.
|OA=1
}}

{{PMID Auto
|PMID=23201894
|Title=Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: a HuGE review and meta-analysis.
}}

{{PMID Auto
|PMID=23645212
|Title=Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma.
}}

{{PMID Auto
|PMID=23790025
|Title=Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China.
}}

{{PMID Auto
|PMID=24754849
|Title=Polymorphism in the epidermal growth factor gene is associated with pre-eclampsia and low birthweight
}}

{{PMID Auto
|PMID=24834259
|Title=The effect of 5'untranslated region polymorphism in EGF gene, rs4444903, on colorectal cancer
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}