{{Rsnum
|rsid=4458523
|Gene=WFS1
|Chromosome=4
|position=6288259
|Orientation=plus
|GMAF=0.2897
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=WFS1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 43.4 | 49.6 | 7.1
| HCB | 93.4 | 6.6 | 0.0
| JPT | 93.8 | 6.2 | 0.0
| YRI | 38.8 | 48.3 | 12.9
| ASW | 36.8 | 38.6 | 24.6
| CHB | 93.4 | 6.6 | 0.0
| CHD | 87.2 | 12.8 | 0.0
| GIH | 33.7 | 58.4 | 7.9
| LWK | 28.2 | 48.2 | 23.6
| MEX | 55.2 | 39.7 | 5.2
| MKK | 25.0 | 50.6 | 24.4
| TSI | 42.2 | 42.2 | 15.7
| HapMapRevision=28
}}{{Report GE
|PubMed=17603484
|Source=journal
|AffyProbeset=SNP_A-2217489
|AffyOrientation=same
|AlleleA=G
|AlleleB=T
|onGW5=1
|rsid=4458523
|ancestral=T
|RiskPopulation=Caucasian (UK)
|RiskAllele=G
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.16
|Disease=Type II Diabetes
|DiseaseSymbol=T2D
|OA=1
}}

rs4458523 is in linkage disequilibrium with a polymorphism that increases susceptibility to Type II Diabetes 1.16 times for carriers of the G allele {{PMID|17603484|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}