{{Rsnum
|rsid=4459653
|Gene=ZNF224
|Chromosome=19
|position=44095462
|Orientation=plus
|GMAF=0.2902
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ZNF224
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 1.8 | 30.1 | 68.1
| HCB | 19.1 | 47.1 | 33.8
| JPT | 11.5 | 38.9 | 49.6
| YRI | 14.3 | 45.6 | 40.1
| ASW | 12.3 | 45.6 | 42.1
| CHB | 19.1 | 47.1 | 33.8
| CHD | 11.9 | 55.0 | 33.0
| GIH | 6.9 | 34.7 | 58.4
| LWK | 16.4 | 46.4 | 37.3
| MEX | 5.2 | 46.6 | 48.3
| MKK | 14.1 | 48.1 | 37.8
| TSI | 4.9 | 25.5 | 69.6
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4459653
|Name_s=
|Gene_s=ZNF224
|Feature=
|Evidence=PubMed ID:19118814
|Annotation=This variant is significantly associated with late-onset Alzheimer disease (LOAD) in a GWAS study with 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162363834
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4459653
|overall_frequency_n=98
|overall_frequency_d=126
|overall_frequency=0.777778
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=84
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}