{{Rsnum
|rsid=4464148
|Gene=SMAD7
|Chromosome=18
|position=48932662
|Orientation=plus
|GMAF=0.2121
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SMAD7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.8 | 37.5 | 52.7
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.0 | 7.1 | 92.9
| YRI | 4.8 | 25.2 | 70.1
| ASW | 1.8 | 31.6 | 66.7
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.9 | 9.2 | 89.9
| GIH | 0.0 | 13.9 | 86.1
| LWK | 5.5 | 25.5 | 69.1
| MEX | 5.2 | 29.3 | 65.5
| MKK | 1.3 | 32.7 | 66.0
| TSI | 20.6 | 41.2 | 38.2
| HapMapRevision=28
}}[[rs4464148]] is one of 3 SNPs in the [[SMAD7]] gene associated with risk for [[colorectal cancer]], based on a large study (7,400+ cases) conducted in the UK. The odds ratios show an increased risk for the minor [[rs4464148]](C) allele; the OR for (C;C) homozygotes is 1.35 (CI: 1.2-1.51), and for (C;T) heterozygotes 1.10 (CI: 1.09-1.21), overall p=7x10<sup>-8</sup>.{{PMID|17934461}}

{{PMID Auto
|PMID=20124488
|Title=Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7
|OA=1
}}

{{PMID Auto
|PMID=21075068
|Title=SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study
}}
{{PMID Auto
|PMID=21097774
|Title=Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
}}
{{PMID Auto
|PMID=21221812
|Title=A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population
}}

{{PMID Auto
|PMID=21910156
|Title=Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women
|OA=1
}}

{{PMID Auto
|PMID=22505654
|Title=GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
}}

{{PMID Auto
|PMID=19155440
|Title=Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=19357349
|Title=Association of common genetic variants in SMAD7 and risk of colon cancer.
|OA=1
}}

{{PMID Auto
|PMID=19395656
|Title=The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.
|OA=1
}}

{{PMID Auto
|PMID=22554650
|Title=Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
|OA=1
}}

{{PMID Auto
|PMID=24448986
|Title=Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}