{{Rsnum
|rsid=4489954
|Gene=MAP2K5
|Chromosome=15
|position=67779737
|Orientation=plus
|GMAF=0.4637
|Gene_s=MAP2K5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 50.0 | 45.5 | 4.5
| HCB | 6.6 | 46.0 | 47.4
| JPT | 9.7 | 41.6 | 48.7
| YRI | 34.7 | 54.4 | 10.9
| ASW | 36.8 | 50.9 | 12.3
| CHB | 6.6 | 46.0 | 47.4
| CHD | 10.1 | 40.4 | 49.5
| GIH | 27.7 | 44.6 | 27.7
| LWK | 50.5 | 39.4 | 10.1
| MEX | 13.8 | 48.3 | 37.9
| MKK | 41.7 | 46.2 | 12.2
| TSI | 48.0 | 39.2 | 12.7
| HapMapRevision=28
}}
[[rs4489954]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.69 (CI: 0.69-0.82) for the (T) minor allele. {{PMID|17637780}}
{{ neighbor
| rsid = 3784709
| distance = 200
}}

{{PMID Auto
|PMID=19223043
|Title=Exploring the genetic link between RLS and [[ADHD]]
}}

{{PharmGKB
|RSID=rs4489954
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs4489954 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355631
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4489954
|overall_frequency_n=67
|overall_frequency_d=128
|overall_frequency=0.523438
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}