{{Rsnum
|rsid=449647
|Gene=APOE
|Chromosome=19
|position=44905307
|Orientation=plus
|GMAF=0.1758
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=APOE
}}{{PMID|19172988|OA=1
}} Significant [[Alzheimer's disease]] associations with were found for [[rs449647]](A;A) and [[rs405509]](G;G) genotypes (positive), and [[rs449647]](A;T) and [[rs405509]](T;T)

{{PMID Auto
|PMID=21263195
|Title=An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease
}}

{{PMID Auto
|PMID=22028770
|Title=APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
|OA=1
}}
{{PMID Auto
|PMID=17434289
|Title=Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.
|OA=1
}}

{{PMID Auto
|PMID=18161859
|Title=Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
|OA=1
}}

{{PMID Auto
|PMID=25085564
|Title=Influence of multiple
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}