{{Rsnum
|rsid=4496877
|Gene=NOS3
|Chromosome=7
|position=150983418
|Orientation=plus
|GMAF=0.2199
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}[[rs4496877]] is a SNP near the [[NOS3]] gene.

Several [[Type-1 diabetes]] patients pools, totaling over 2,000 patients, plus a meta-analysis were involved in a study concluding that in such patients, the [[rs4496877]] was associated with higher risk for nephropathy. The odds ratio associated with [[rs4496877]](T) was 1.26 (p = 0.002, CI: 1.08-1.47).{{PMID|20962522}}

A proxy for this SNP (pairwise linkage of 0.96) is [[rs1800783]].
{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 36.3 | 47.8 | 15.9
| HCB | 78.8 | 19.7 | 1.5
| JPT | 80.4 | 19.6 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 78.8 | 19.7 | 1.5
| CHD | 79.6 | 17.6 | 2.8
| GIH | 64.4 | 27.7 | 7.9
| LWK | 99.1 | 0.9 | 0.0
| MEX | 60.3 | 32.8 | 6.9
| MKK | 81.8 | 18.2 | 0.0
| TSI | 26.5 | 54.9 | 18.6
| HapMapRevision=28
}}

{{PMID Auto
|PMID=19505917
|Title=Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}