{{Rsnum
|rsid=450046
|Gene=PRODH
|Chromosome=22
|position=18913491
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.08678
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PRODH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 12.5 | 87.5
| HCB | 0.7 | 5.8 | 93.4
| JPT | 0.0 | 5.3 | 94.7
| YRI | 4.8 | 29.9 | 65.3
| ASW | 5.3 | 24.6 | 70.2
| CHB | 0.7 | 5.8 | 93.4
| CHD | 0.0 | 4.6 | 95.4
| GIH | 1.0 | 13.0 | 86.0
| LWK | 9.1 | 33.6 | 57.3
| MEX | 0.0 | 13.8 | 86.2
| MKK | 3.8 | 33.3 | 62.8
| TSI | 0.0 | 10.8 | 89.2
| HapMapRevision=28
}}
{{omim
|desc=HYPERPROLINEMIA, TYPE I
|id=606810
|rsnum=450046
|variant=0006
}}

also referred to as 1766A/G

[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000252 plos] [[rs450046]] was most strongly positively associated with [[schizophrenia]] in families.

{{PMID|19232576}} [[rs372055]](C), [[rs450046]](G), [[rs385440]](A) haplotype carriers (n = 32) exhibited attenuated PPI + verbal memory (p < .001) as well as higher anxiety (p < .004) and schizotypy (p < .008) compared to noncarriers (n = 185)

{{ClinVar
|rsid=450046
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=18901004
|CHROM=22
|GMAF=0.087
|dbSNPBuildID=80
|SSR=0
|SAO=1
|VP=0x05016800000015051f110100
|WGT=0
|VC=SNV
|CLNALLE=0
|CLNHGVS=NC_000022.10:g.18901004C\x3d
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=606810.0006
|CLNSIG=255
|CLNCUI=C0268529
|CLNDBN=Proline dehydrogenase deficiency; Schizophrenia 4
|Disease=Proline dehydrogenase deficiency; Schizophrenia 4
|CLNACC=RCV000004222.1; RCV000004223.1
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.08678; 0.9132
|CLNDSDB=MedGen:OMIM:Orphanet:SNOMED_CT; MedGen:OMIM
|CLNDSDBID=C0268529:239500:419:61071003; C1833247:600850
|COMMON=1
|GENEINFO=PRODH:5625
|GENE_ID=5625
|GENE_NAME=PRODH
}}

{{PMID|17708757|OA=1
}} Genome bioinformatic analysis of nonsynonymous SNPs.

{{PMID|18408230|OA=1
}} Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?

{{PMID|18989458|OA=1
}} Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function.

{{PMID|19693005|OA=1
}} Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

{{GET Evidence
|gene=PRODH
|aa_change=Arg413Gln
|aa_change_short=R413Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs450046
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}