{{Rsnum
|rsid=4504469
|Gene=KIAA0319
|Chromosome=6
|position=24588656
|Orientation=plus
|GMAF=0.2332
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KIAA0319
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 38.7 | 46.8 | 14.5
| HCB | 81.8 | 18.2 | 0.0
| JPT | 72.1 | 25.6 | 2.3
| YRI | 98.4 | 1.6 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 81.8 | 18.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[Rs4504469]], a nonsynonymous SNP in exon 4 of the [[KIAA0319]] gene, is in a region that crops up in several independent studies as likely to associated with [[dyslexia]]. The risk allele in the Caucasian populations studied is (T).

The odds ratio in a study of case:control study of ~400 Caucasians associated with [[rs4504469]](T) is 1.51 (CI: 1.17â€“1.95, p = 0.002). {{PMID|15717286|OA=1
}}

{{omim
|desc=KIAA0319 GENE; KIAA0319
|id=609269
|rsnum=4504469
}}

{{omim
|id=600202
|rsnum=4504469
}}

{{ClinVar
|rsid=4504469
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=24588884
|CHROM=6
|GMAF=0.2326
|dbSNPBuildID=111
|SSR=0
|SAO=0
|VP=0x050068000a0115051f110100
|GENEINFO=KIAA0319:9856
|GENE_NAME=KIAA0319
|GENE_ID=9856
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.24588884C>T
|CLNSIG=1
|Tags=PM;PMC;NSM;REF;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7668; 0.2332
|COMMON=1
}}

{{PMID|15514892|OA=1
}} A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.

{{PMID|16385449|OA=1
}} Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.

{{PMID|19325871|OA=1
}} A common variant associated with dyslexia reduces expression of the KIAA0319 gene.

{{PMID|19997522|OA=1
}} Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.

{{GET Evidence
|gene=KIAA0319
|aa_change=Ala311Thr
|aa_change_short=A311T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4504469
|overall_frequency_n=3182
|overall_frequency_d=10758
|overall_frequency=0.29578
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23677054
|Title=Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}