{{Rsnum
|rsid=4537545
|Gene=IL6R
|Chromosome=1
|position=154446403
|Orientation=plus
|GMAF=0.4601
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL6R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 40.9 | 44.5 | 14.5
| HCB | 35.3 | 48.5 | 16.2
| JPT | 44.2 | 41.6 | 14.2
| YRI | 4.8 | 46.9 | 48.3
| ASW | 19.3 | 45.6 | 35.1
| CHB | 35.3 | 48.5 | 16.2
| CHD | 33.9 | 45.0 | 21.1
| GIH | 50.5 | 45.5 | 4.0
| LWK | 5.6 | 45.4 | 49.1
| MEX | 27.6 | 39.7 | 32.8
| MKK | 12.3 | 45.5 | 42.2
| TSI | 35.3 | 49.0 | 15.7
| HapMapRevision=28
}}{{PMID Auto
|PMID=19567438
|Title=Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
|OA=1
}}

{{PMID Auto
|PMID=21552154
|Title=Common genetic variation in the IGF1 associates with maximal force output
}}

{{PMID|17671508|OA=1
}} A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

{{PMID|18276608}} Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.

{{PMID|19197348|OA=1
}} Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

{{PMID|19249341|OA=1
}} Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

{{PMID|20031577|OA=1
}} Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4537545
|overall_frequency_n=62
|overall_frequency_d=128
|overall_frequency=0.484375
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23372742
|Title=Interleukin-6 Receptor Polymorphism Is Prevalent in HIV-negative Castleman Disease and Is Associated with Increased Soluble Interleukin-6 Receptor Levels
|OA=1
}}

{{PMID Auto
|PMID=24971461
|Title=Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}