{{Rsnum 
|rsid = 45477792
|Gene =  KCNA5
|geno1 = (T;T)
|geno2 = (C;T)
|geno3 = (C;C)
|ReferenceAllele=C
|MissenseAllele=T
|Orientation=plus
|Chromosome=12
|position=5045742
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=17221812
|Gene_s=KCNA5
}}This SNP, also known as P532L, affecting an amino acid in exon 1 of the [[KCNA5]] potassium channel gene, may mediate the response to drugs such as quinidine.

The risk allele is [[rs45477792(T)]], and carriers receiving [[quinidine]] or [[propafenone]] for the treatment of cardiac [[arrhythmias]] may be resistant to the drug (and thus treatment). Note that this allele is rare; it was not observed in Caucasian or Asian populations, however it is reported to be present at a frequency of 0.8% (i.e. less than 1%) among African-Americans.
{{PMID|15735608}}
{{ neighbor
| rsid = 45438698
| distance = 138
}}

{{on chip | HumanOmni1Quad}}