{{Rsnum
|rsid=454886
|Gene=APC
|Chromosome=5
|position=112810420
|Orientation=plus
|GMAF=0.3655
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=APC
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.6 | 50.4 | 38.9
| HCB | 45.2 | 41.5 | 13.3
| JPT | 43.6 | 48.2 | 8.2
| YRI | 0.0 | 3.4 | 96.6
| ASW | 0.0 | 14.0 | 86.0
| CHB | 45.2 | 41.5 | 13.3
| CHD | 27.1 | 57.0 | 15.9
| GIH | 17.8 | 38.6 | 43.6
| LWK | 0.0 | 11.8 | 88.2
| MEX | 24.1 | 65.5 | 10.3
| MKK | 2.0 | 17.8 | 80.3
| TSI | 8.0 | 39.0 | 53.0
| HapMapRevision=28
}}

{{PMID|18708403|OA=1
}} 798 invasive [[breast cancer]] cases and 843 unaffected controls
*[[rs454886]] per allele odds ratio, 1.23; 95% confidence intervals, 1.05-1.43; P(trend) = 0.01

{{PharmGKB
|RSID=rs454886
|Name_s=
|Gene_s=APC
|Feature=
|Evidence=PubMed ID:18708403
|Annotation=In 798 invasive breast cancer cases and 843 unaffected controls this SNP in the APC tumor suppressor gene was associated with increased breast cancer risk.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162191343
}}

{{omim
|id=114500
|rsnum=454886
}}

{{ClinVar
|rsid=454886
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=112146117
|CHROM=5
|GMAF=0.3654
|dbSNPBuildID=80
|SSR=0
|SAO=1
|VP=0x050068000000150517110100
|GENEINFO=APC:324
|GENE_NAME=APC
|GENE_ID=324
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.112146117A>G
|CLNORIGIN=0
|CLNSIG=255
|CLNCUI=114500
|CLNDBN=Familial colorectal cancer
|Tags=RV;PM;PMC;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6345; 0.3655
|CLNDSDB=GeneReviews:MedGen:OMIM
|CLNDSDBID=NBK1211:CN029768:114500
|COMMON=1
|Disease=Familial colorectal cancer
|CLNACC=RCV000074069.1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs454886
|overall_frequency_n=37
|overall_frequency_d=128
|overall_frequency=0.289062
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}