{{Rsnum
|rsid=45511401
|Gene=ABCC1
|Chromosome=16
|position=16079375
|Orientation=plus
|GMAF=0.02204
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ABCC1
}}{{PharmGKB
|RSID=rs45511401
|Name_s=ABCC1:2012G>T, mRNA 2187G>T, Gly671Val
|Gene_s=ABCC1
|Feature=
|Evidence=PubMed ID:18851956
|Annotation=Risk or phenotype-associated allele: 2012GT (671Gly/Val) genotype. Phenotype: Carriers the heterozygous 2012GT (671Gly/Val) genotype had lower serum HDL cholesterol than the GG (671Gly/Gly) genotype carriers (p = 0.015). Study size: 136. Study population/ethnicity: Hypercholesterolemic individuals, treated with atorvastatin (10mg/day/4 weeks), evaluated for CAD risk factors at the Institute Dante Pazzanese of Cardiology and the Hospital of the Sao Paulo University in Sao Paulo City, Brazil. Significance metric(s): p = 0.015. Type of association: GN; PD; FA
|Drugs=atorvastatin
|Drug Classes=
|Diseases=Coronary Artery Disease; Hypercholesterolemia
|Curation Level=Curated
|PharmGKB Accession ID=PA165110751
}}

{{PharmGKB
|RSID=rs45511401
|Name_s=MRP1 Gly671Val; ABCC1 rs45511401
|Gene_s=ABCC1
|Feature=
|Evidence=PubMed ID:16330681
|Annotation=Risk or phenotype-associated allele: T. Phenotype: This SNP was associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 3.6; 95% CI, 1.6 to 8.4. Type of association: PD; ADR; TOX.
|Drugs=doxorubicin
|Drug Classes=
|Diseases=Arrhythmias, Cardiac; Cardiomyopathies; Drug Toxicity; Lymphoma, Non-Hodgkin
|Curation Level=Curated
|PharmGKB Accession ID=PA165291812
}}

{{PharmGKB
|RSID=rs45511401
|Name_s=G671V
|Gene_s=ABCC1
|Feature=
|Evidence=PubMed ID:11721885
|Annotation=system: membrane vessicles from HEK cells transfected with WT and variant; FA: transport of leukotriene C4, 17beta-estradiol 17beta-(D)-glucuronide, and estrone sulfate were the same for WT and variant
|Drugs=estradiol; estrone
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165282035
}}

{{PMID|22293538|OA=1
}} The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

{{GET Evidence
|gene=ABCC1
|aa_change=Gly671Val
|aa_change_short=G671V
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs45511401
|overall_frequency_n=454
|overall_frequency_d=10416
|overall_frequency=0.0435868
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=3
|n_articles_annotated=0
|in_pharmgkb=Y
|nblosum100=8
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23396606
|Title=Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}