{{Rsnum
|rsid=4553808
|Gene=CTLA4
|Chromosome=2
|position=203866282
|Orientation=plus
|GMAF=0.152
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CTLA4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 78.9 | 19.3 | 1.8
| HCB | 84.6 | 15.4 | 0.0
| JPT | 91.7 | 8.3 | 0.0
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 84.6 | 15.4 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4553808]], also known as A/G-1661, is a SNP in the upstream activator sequence of the cytotoxic T lymphocyte associated antigen-4 [[CTLA4]] gene. This gene encodes the CD152 antigen.

A study of 165 Swedish [[myasthenia gravis]] patients concluded that the [[rs4553808]](G;G) homozygotes had an odds ratio of 0.05 (CI: 0.00286-0.874, p=0.0023) for the disease compared to healthy individuals, while the [[rs4553808]](G) allele showed a less dramatic reduction in risk, with an odds ratio of 0.578 (CI: 0.373-0.897, p=0.015).{{PMID|18088253}}
{{ neighbor
| rsid = 733618
| distance = 61
}}
{{ neighbor
| rsid = 11571316
| distance = 84
}}

{{PMID Auto
|PMID=19438904
|Title=Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
}}

{{PMID Auto
|PMID=22178694
|Title=Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematological malignancies
}}

{{PMID Auto
|PMID=15452244
|Title=Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
|OA=1
}}

{{PMID Auto
|PMID=17825114
|Title=Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=18528295
|Title=Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.
|OA=1
}}

{{PMID Auto
|PMID=19609446
|Title=CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.
|OA=1
}}

{{PMID Auto
|PMID=19622768
|Title=CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
|OA=1
}}

{{PMID Auto
|PMID=20352109
|Title=Association of the CTLA4 gene with Graves' disease in the Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=21228734
|Title=Genetic variation associated with bortezomib-induced peripheral neuropathy.
}}

{{PMID Auto
|PMID=22418270
|Title=Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients.
}}

{{PMID Auto
|PMID=23480667
|Title=Cytotoxic T-Lymphocyte Antigen-4 Genetic Variants and Risk of Ewing's Sarcoma
}}

{{PMID Auto
|PMID=24015180
|Title=CTLA4 Gene Polymorphisms Influence the Incidence of Infection after Renal Transplantation in Chinese Recipients
|OA=1
}}

{{PMID Auto
|PMID=24313821
|Title=Association of CTLA-4 Gene Polymorphism with End-Stage Renal Disease and Renal Allograft Outcome
}}

{{PMID Auto
|PMID=23628397
|Title=Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients
}}

{{PMID Auto
|PMID=23261408
|Title=-1722T/C polymorphism (rs733618) of CTLA-4 significantly associated with systemic lupus erythematosus (SLE): a comprehensive meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}