{{Rsnum
|rsid=45539432
|Gene=PINK1
|Chromosome=1
|position=20649109
|Orientation=plus
|ReferenceAllele=C
|GMAF=0.0004591
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PINK1,PINK1-AS
}}[[rs45539432]], also known as Gln456Ter or Q456X, is a SNP in the [[PINK1]] gene. In one German family studied, [[rs45539432]](T;T) homozygotes exhibited early onset [[Parkinson's disease]]. Of the [[rs45539432]](C;T) heterozygotes, half showed no signs of Parkinson's, but the other half had subtle signs of disease, consisting of unilaterally reduced or absent arm swing and rigidity.{{PMID|16769864}}

{{omim
|id=608309
|rsnum=45539432
|variant=0012
}}

{{ClinVar
|rsid=45539432
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=20649109
|CHROM=1
|GMAF=0.0005
|dbSNPBuildID=127
|SSR=0
|SAO=1
|VP=0x050260000605000416110100
|GENEINFO=PINK1-AS:100861548; PINK1:65018
|GENE_NAME=PINK1-AS; PINK1
|GENE_ID=100861548; 65018
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.20649109C>T
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NM_032409.2:c.1366C>T; NR_046507.1:n.3085G>A; 608309.0012
|CLNSIG=5
|CLNCUI=C1853833
|CLNDBN=Parkinson disease 6, autosomal recessive early-onset
|Disease=Parkinson disease 6
|CLNACC=RCV000002516.1
|Tags=PM;S3D;NSN;REF;ASP;HD;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9995; 0.0004591
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK26472:C1853833:605909:ORPHA2828
|COMMON=0
}}

{{on chip | HumanOmni1Quad}}