{{Rsnum
|rsid=4570625
|Gene=TPH2
|Chromosome=12
|position=71938143
|Orientation=plus
|GMAF=0.3632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TPH2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 64.6 | 29.2 | 6.2
| HCB | 22.1 | 52.2 | 25.7
| JPT | 24.8 | 51.3 | 23.9
| YRI | 37.4 | 49.0 | 13.6
| ASW | 45.6 | 43.9 | 10.5
| CHB | 22.1 | 52.2 | 25.7
| CHD | 20.2 | 48.6 | 31.2
| GIH | 62.4 | 31.7 | 5.9
| LWK | 32.1 | 47.7 | 20.2
| MEX | 43.9 | 47.4 | 8.8
| MKK | 34.6 | 46.8 | 18.6
| TSI | 58.8 | 32.4 | 8.8
| HapMapRevision=28
}}[[rs4570625]], also known as G-703T, is a SNP in the tryptophan hydroxylase 2 [[TPH2]] gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:

* {{PMID|16146581}} [[rs4570625]] and [[rs4565946]] linked to the pathogenesis of early-onset [[obsessive compulsive disorder]]

* [[rs4570625]] and [[rs11178997]] in [[TPH2]]'s regulatory region display preferential transmission

* {{PMID|19052197}} [[rs4570625]](G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in [[anxiety]] symptoms.

[http://genes2brains2mentalhealth.wordpress.com/2008/12/06/rs4570625-gg-makes-me-a-believer/ g2b2mh] is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe [http://scienceblogs.com/geneticfuture/2008/12/neuroskeptic_savages_the_place.php not]

{{PMID|19132526}} panic disorder with a possible gender-dependent effect

{{ neighbor
| rsid = 11178997
| distance = 230
}}

{{omim
|id=143465
|desc=ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
|rsnum=4570625
}}

{{omim
|desc=TRYPTOPHAN HYDROXYLASE 2; TPH2
|id=607478
|rsnum=4570625
}}
{{PMID Auto
|PMID=19894072
|Title=A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
}}

{{PMID Auto
|PMID=18427560
|Title=Tph2 gene variants modulate response control processes in adult [[ADHD]] patients and healthy individuals
}}

{{PMID Auto
|PMID=20331984
|Title=Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes
}}

{{omim
|id=613003
|rsnum=4570625
}}

{{PMID Auto
|PMID=21396719
|Title=Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
}}

{{PMID Auto
|PMID=22693556
|Title=TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=22698518
|Title=Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
}}

{{PMID|16116490}} Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

{{PMID|17176491}} Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

{{PMID|17176492}} Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

{{PMID|17346350|OA=1
}} Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

{{PMID|17568567}} Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.

{{PMID|17892388}} Genetic variation of serotonin function and cognitive control.

{{PMID|18782386|OA=1
}} Tryptophan hydroxylase 2 gene and alcohol use among college students.

{{PMID|19077664|OA=1
}} Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

{{PMID|19361870}} TPH2 gene variants and anxiety during alcohol detoxification outcome.

{{PMID|19742166|OA=1
}} Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

{{PMID|20126463|OA=1
}} Alternative splicing and extensive RNA editing of human TPH2 transcripts.

{{PMID|20938755}} Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.

{{PMID|21172166|OA=1
}} Pharmacogenetics of antidepressant response.

{{PMID|21418063}} Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.

{{PMID|22322887}} Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

{{PMID|22392150}} Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.

{{PMID Auto
|PMID=22868061
|Title=The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism
}}

{{PMID Auto
|PMID=24304270
|Title=Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants
}}

{{PMID Auto
|PMID=24458851
|Title=Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches
}}

{{PMID Auto
|PMID=22655589
|Title=Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
}}

{{PMID Auto
|PMID=22835848
|Title=Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders.
}}

{{PMID Auto
|PMID=23628433
|Title=Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}