{{Rsnum
|rsid=4588
|Gene=GC
|Chromosome=4
|position=71752606
|Orientation=minus
|GMAF=0.2163
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=GC
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 4.5 | 44.6 | 50.9
| HCB | 8.8 | 44.9 | 46.3
| JPT | 2.7 | 43.8 | 53.6
| YRI | 0.0 | 8.2 | 91.8
| ASW | 0.0 | 9.1 | 90.9
| CHB | 8.8 | 44.9 | 46.3
| CHD | 10.1 | 37.6 | 52.3
| GIH | 6.9 | 49.5 | 43.6
| LWK | 0.9 | 11.0 | 88.1
| MEX | 1.8 | 46.4 | 51.8
| MKK | 2.6 | 15.5 | 81.9
| TSI | 5.9 | 39.2 | 54.9
| HapMapRevision=28
}}

see [[rs2282679]], a near-perfect proxy for [[rs4588]]

{{PMID Auto
|PMID=19488670
|Title=Vitamin D binding protein genotype and osteoporosis
|OA=1
}}

{{PMID Auto
|PMID=20363324
|Title=A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
}}
{{PMID Auto
|PMID=19996341
|Title=Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
}}
{{PMID Auto
|PMID=20812960
|Title=Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas
}}

{{omim
|id=139200
|rsnum=4588
|variant=0001
}}

{{PMID Auto
|PMID=21844098
|Title=Reduced Serum Vitamin D-Binding Protein Levels Are Associated With Type 1 Diabetes
|OA=1
}}

{{PMID Auto
|PMID=22328951
|Title=GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer susceptibility in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=22213340
|Title=25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
}}

{{PMID Auto
|PMID=22610885
|Title=Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C.
}}

{{ClinVar
|rsid=4588
|Reversed=1
|FwdREF=C
|FwdALT=A
|REF=G
|ALT=T
|RSPOS=72618323
|CHROM=4
|GMAF=0.2157
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05036800000015051f110100
|GENEINFO=GC:2638
|GENE_NAME=GC
|GENE_ID=2638
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000004.11:g.72618323G>T
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7837; 0.2163
|CLNACC=RCV000017356.1
|CLNDBN=GC1/GC2 POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=139200.0001
|COMMON=1
|Disease=GC1/GC2 POLYMORPHISM
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|17054776|OA=1
}} The genetics of chronic obstructive pulmonary disease.

{{PMID|17244366|OA=1
}} Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study.

{{PMID|18559548}} The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.

{{PMID|18593774|OA=1
}} Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.

{{PMID|19116321}} Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.

{{PMID|19131662|OA=1
}} A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

{{PMID|19263529|OA=1
}} Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

{{PMID|19330901|OA=1
}} Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

{{PMID|19559392|OA=1
}} A candidate gene association study of 77 polymorphisms in migraine.

{{PMID|20031567|OA=1
}} An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

{{PMID|21972121}} Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.

{{PMID|22583563|OA=1
}} Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.

{{GET Evidence
|gene=GC
|aa_change=Thr436Lys
|aa_change_short=T436K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4588
|overall_frequency_n=2433
|overall_frequency_d=10758
|overall_frequency=0.226157
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23505139
|Title=An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population
}}

{{PMID Auto
|PMID=23169318
|Title=Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients
}}

{{PMID Auto
|PMID=23734748
|Title=Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
|OA=1
}}

{{PMID Auto
|PMID=23556437
|Title=Changes in circulating 25-hydroxyvitamin D according to vitamin D binding protein genotypes after vitamin D₃ or D₂supplementation
|OA=1
}}

{{PMID Auto
|PMID=23456391
|Title=Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes
|OA=1
}}

{{PMID Auto
|PMID=24568525
|Title=Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer
}}

{{PMID Auto
|PMID=23070913
|Title=Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients.
}}

{{PMID Auto
|PMID=23191998
|Title=Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults.
}}

{{PMID Auto
|PMID=23427793
|Title=Common variants of the vitamin D binding protein gene and adverse health outcomes.
|OA=1
}}

{{PMID Auto
|PMID=23923033
|Title=The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study
}}

{{PMID Auto
|PMID=25174667
|Title=Environmental and Genetic Determinants of Vitamin D Insufficiency in 12-month-old Infants
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}