{{Rsnum
|rsid=4607517
|Chromosome=7
|position=44196069
|Orientation=plus
|GMAF=0.1648
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 26.5 | 67.3
| HCB | 4.4 | 35.0 | 60.6
| JPT | 0.9 | 38.1 | 61.1
| YRI | 0.0 | 12.2 | 87.8
| ASW | 1.8 | 15.8 | 82.5
| CHB | 4.4 | 35.0 | 60.6
| CHD | 3.7 | 32.4 | 63.9
| GIH | 0.0 | 23.8 | 76.2
| LWK | 0.0 | 18.2 | 81.8
| MEX | 1.7 | 25.9 | 72.4
| MKK | 3.2 | 30.1 | 66.7
| TSI | 1.0 | 37.3 | 61.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060907
|Trait=Fasting plasma glucose
|Title=Variants in MTNR1B influence fasting glucose levels
|RiskAllele=A
|Pval=1E-25
|OR=0.06
|ORtxt=[0.05-0.07] mmol/l increase
|OA=1
}}

{{PMID Auto
|PMID=19741166
|Title=Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
|OA=1
}}

{{PharmGKB
|RSID=rs4607517
|Name_s=
|Gene_s=GCK, YKT6
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype 1: In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 118,500. Significance metric(s): p = 6.5 x 10(-92). Phenotype 2: In the same study, this SNP was found to be associated with HOMA-B (homeostasis model assessment of beta-cell function). Study size: 94,112. Significance metric(s): p = 1.8 x 10(-16). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281935
}}

{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=A
|Pval=2E-16
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20839289
|Title=Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|OA=1
}}

{{PharmGKB
|RSID=rs4607517
|Name_s=
|Gene_s=GCK, YKT6
|Feature=
|Evidence=PubMed ID:19060907; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in MTNR1B influence fasting glucose levels. (Initial Sample Size: 35,812 individuals; Replication Sample Size: NR); (Region: 7p13; Reported Gene(s): GCK; Risk Allele: rs4607517-A); (p-value= 1E-25).This variant is associated with Fasting plasma glucose.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740303
}}
{{PMID Auto
|PMID=21036910
|Title=Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
|OA=1
}}

{{omim
|id=613219
|rsnum=4607517
}}

{{PMID Auto
|PMID=21887289
|Title=Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
|OA=1
}}

{{PMID Auto
|PMID=22096510
|Title=Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population
|OA=1
}}

{{PMID Auto GWAS
|PMID=22508271
|Trait=None
|Title=Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).
|RiskAllele=G
|Pval=1E-7
|OR=1.1500
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20870969
|Title=Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
|OA=1
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=8E-56
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4607517
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23029294
|Title=Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
|OA=1
}}

{{PMID Auto
|PMID=22698489
|Title=Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}