{{Rsnum
|rsid=4646903
|Gene=CYP1A1
|Chromosome=15
|position=74719300
|Orientation=minus
|GMAF=0.2433
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=CYP1A1
}}{{PMID Auto
|PMID=19608585
|Title=Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer
}}
{{PMID Auto
|PMID=19650794
|Title=CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients
}}

{{PharmGKB
|RSID=rs4646903
|Name_s=CYP1A1*2A; CYP1A1:MspI; CYP1A1:6235T>C; CYP1A1:3801T>C; CYP1A1:m1
|Gene_s=CYP1A1
|Feature=
|Evidence=PubMed ID:16407087; PubMed ID:16484137
|Annotation=No association to nerve damage from n-hexane, highest GPT levels correlated with homozygotes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145036
}}
{{PMID Auto
|PMID=20544687
|Title=Evidence that genetic variants of metabolic detoxication and cell cycle control are not related to gallbladder cancer risk in Chilean women
}}
{{PMID Auto
|PMID=21359562
|Title=Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study
}}{{PMID|16949388}} CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal.

{{PMID|17116718|OA=1
}} Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.

{{PMID|17429315}} Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.

{{PMID|17603290}} Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.

{{PMID|18268125|OA=1
}} Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18628428|OA=1
}} Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

{{PMID|18691756|OA=1
}} Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.

{{PMID|18763031|OA=1
}} CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|18941913|OA=1
}} Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

{{PMID|18990750|OA=1
}} Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.

{{PMID|19127255|OA=1
}} Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

{{PMID|19174490|OA=1
}} Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

{{PMID|19267064}} [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].

{{PMID|19387820|OA=1
}} Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

{{PMID|19479063|OA=1
}} Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.

{{PMID|19537956|OA=1
}} CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women.

{{PMID|19630952|OA=1
}} Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

{{PMID|19679043|OA=1
}} African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.

{{PMID|19954069}} [Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms].

{{PMID|20878621}} Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.

{{PMID|21429951}} Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

{{PMID|21741876}} Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.

{{PMID|21897271}} Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure.

{{PMID|22200898}} Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE).

{{PMID|22525558}} Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population.{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4646903
|overall_frequency_n=28
|overall_frequency_d=128
|overall_frequency=0.21875
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}
{{PMID Auto
|PMID=23528250
|Title=Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women
}}
{{PMID Auto
|PMID=23686565
|Title=Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection
}}
{{PMID Auto
|PMID=23906684
|Title=Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants
}}
{{PMID Auto
|PMID=24499375
|Title=Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
}}{{PMID Auto
|PMID=22949524
|Title=Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides.
}}

{{PMID Auto
|PMID=23107763
|Title=Host genetic risk factors for community-acquired pneumonia.
}}

{{PMID Auto
|PMID=23130019
|Title=Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.
|OA=1
}}

{{PMID Auto
|PMID=23178447
|Title=Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.
}}

{{PMID Auto
|PMID=23661361
|Title=The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.
}}

{{PMID Auto
|PMID=23848208
|Title=CYP1A1 gene polymorphisms and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
}}

{{PMID Auto
|PMID=23852617
|Title=Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
}}
{{PMID Auto
|PMID=24068433
|Title=CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications
}}