{{Rsnum
|rsid=4648298
|Gene=PTGS2
|Chromosome=1
|position=186672550
|Orientation=minus
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PTGS2
}}{{PMID Auto
|PMID=19468846
|Title=Effect of COX2 -765G&gt;C and c.3618A&gt;G polymorphisms on the risk and survival of sporadic colorectal cancer
}}

{{PharmGKB
|RSID=rs4648298
|Name_s=PTGS2:9850A>G
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:15173859
|Annotation=Increased risk for colorectal cancer.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145107
}}

{{ population diversity
| geno1 = (A;A)
| geno2 = (A;G)
| geno3 = 
| CEU | 96.5 | 3.5 | 0
| CHB | 0 | 0 | 0
| JPT | 97.7 | 2.3 | 0
| YRI | 0 | 0 | 0
}}

{{PMID Auto
|PMID=17214885
|Title=A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.
|OA=1
}}

{{PMID Auto
|PMID=18085997
|Title=Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4648298
|overall_frequency_n=1
|overall_frequency_d=128
|overall_frequency=0.0078125
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}