{{Rsnum
|rsid=4648317
|Gene=DRD2
|Chromosome=11
|position=113460810
|Orientation=minus
|GMAF=0.2365
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DRD2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.2 | 23.0 | 1.8
| HCB | 35.8 | 43.1 | 21.2
| JPT | 38.9 | 46.9 | 14.2
| YRI | 72.8 | 24.5 | 2.7
| ASW | 75.4 | 21.1 | 3.5
| CHB | 35.8 | 43.1 | 21.2
| CHD | 35.2 | 52.8 | 12.0
| GIH | 64.4 | 33.7 | 2.0
| LWK | 78.2 | 19.1 | 2.7
| MEX | 41.4 | 50.0 | 8.6
| MKK | 66.0 | 32.1 | 1.9
| TSI | 68.6 | 23.5 | 7.8
| HapMapRevision=28
}}[[rs4648317]], a SNP in the dopamine D2 receptor [[DRD2]] gene, has been linked to higher rates of smoking and higher [[nicotine dependence]] scores, based on a study of ~220 adolescents. The risk allele [[rs4648317]](T).{{PMID|18434921}}

{{PMID Auto
|PMID=19373123
|Title=Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
}}

{{PMID Auto
|PMID=19512960
|Title=Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
}}
{{PMID Auto
|PMID=19968402
|Title=Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
|OA=1
}}

{{PMID Auto
|PMID=18077373
|Title=Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
|OA=1
}}

{{PMID Auto
|PMID=22244514
|Title=Sensorimotor gating and D2 receptor signalling: evidence from a molecular genetic approach.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}