{{Rsnum
|rsid=4653436
|Chromosome=1
|position=225807509
|Orientation=plus
|GMAF=0.2672
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 46.0 | 43.4
| HCB | 6.7 | 37.3 | 56.0
| JPT | 8.3 | 54.1 | 37.6
| YRI | 2.1 | 11.7 | 86.2
| ASW | 5.3 | 36.8 | 57.9
| CHB | 6.7 | 37.3 | 56.0
| CHD | 1.9 | 33.6 | 64.5
| GIH | 4.0 | 38.0 | 58.0
| LWK | 4.6 | 28.4 | 67.0
| MEX | 5.2 | 39.7 | 55.2
| MKK | 3.2 | 29.7 | 67.1
| TSI | 12.0 | 47.0 | 41.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=20842355
|Title=VKORC1-1639G&gt;A, CYP2C9, EPHX1691A&gt;G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
}}

{{PharmGKB
|RSID=rs4653436
|Name_s=EPHX1, upstream G/A
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19794411
|Annotation=Risk or phenotype-associated allele: undetermined. Phenotype: The variant allele was not associated with warfarin maintenance dose variability (p = 0.4450). Study size: 283. Study population/ethnicity: Hospitalized Caucasian patients aged 75 years or older, recruited Sep 2002-Nov 2004 in Ivry, France, and Oct 2005-Mar 2008 from 14 French centers. Significance metric(s): not significant. Type of association: GN; PK.
|Drugs=warfarin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165111651
}}

{{PMID Auto
|PMID=17048007
|Title=Association of warfarin dose with genes involved in its action and metabolism.
|OA=1
}}

{{PMID Auto
|PMID=18574025
|Title=The largest prospective warfarin-treated cohort supports genetic forecasting.
|OA=1
}}

{{PMID Auto
|PMID=18680736
|Title=Genetic factors contribute to patient-specific warfarin dose for Han Chinese.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4653436
|overall_frequency_n=26
|overall_frequency_d=126
|overall_frequency=0.206349
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}