{{Rsnum
|rsid=4654748
|Gene=NBPF3
|Chromosome=1
|position=21459575
|Orientation=plus
|GMAF=0.4141
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NBPF3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 33.6 | 46.9 | 19.5
| HCB | 15.3 | 50.4 | 34.3
| JPT | 23.9 | 57.5 | 18.6
| YRI | 87.1 | 12.9 | 0.0
| ASW | 71.9 | 28.1 | 0.0
| CHB | 15.3 | 50.4 | 34.3
| CHD | 16.5 | 56.0 | 27.5
| GIH | 38.6 | 48.5 | 12.9
| LWK | 89.1 | 10.0 | 0.9
| MEX | 29.3 | 34.5 | 36.2
| MKK | 51.9 | 43.6 | 4.5
| TSI | 21.6 | 51.0 | 27.5
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19303062
|Trait=Folate pathway vitamins
|Title=Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
|RiskAllele=C
|Pval=8E-18
|OR=1.45
|ORtxt=[0.90-2.00] ng/ml decrease
|OA=1
}}

{{PharmGKB
|RSID=rs4654748
|Name_s=
|Gene_s=NBPF3
|Feature=
|Evidence=PubMed ID:19303062
|Annotation=The C allele of this SNP is associated with lower blood concentration of vitamin B6 (Combined studies of Tuscan Italians ( inCHIANTI:N =1175 and Progetto Nutrizione study:N = 687) found 1.45 ng/mL lower vitamin B6 per copy of C (p = 8.3 x 10 (-18)))
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164918286
}}

{{PharmGKB
|RSID=rs4654748
|Name_s=
|Gene_s=NBPF3
|Feature=
|Evidence=PubMed ID:19303062; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations. (Initial Sample Size: 2,934 individuals; Replication Sample Size: 686 individuals); (Region: 1p36.12; Reported Gene(s): ALPL; Risk Allele: rs4654748-C); (p-value= 0.000000000000000008).This variant is associated with Folate pathway vitamins.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739921
}}

{{omim
|id=612957
|rsnum=4654748
}}

This is one of the SNPs reported by [[NutraHacker SNPs|NutraHacker]].

{{PMID|21115529|OA=1
}} Genetics and genomics of human aging.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4654748
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}