{{Rsnum
|rsid=4656461
|Chromosome=1
|position=165717968
|Orientation=plus
|GMAF=0.1405
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 73.5 | 23.9 | 2.7
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 58.5 | 35.4 | 6.1
| ASW | 54.4 | 42.1 | 3.5
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 94.1 | 5.9 | 0.0
| LWK | 43.1 | 47.7 | 9.2
| MEX | 58.6 | 41.4 | 0.0
| MKK | 48.1 | 43.6 | 8.3
| TSI | 78.4 | 21.6 | 0.0
| HapMapRevision=28
}}[[rs4656461]] is a SNP near the [[TMCO1]] gene.

A (GWA) study for open-angle [[glaucoma]] (OAG) blindness ultimately based on ~1500 cases concluded that the rather rare [[rs4656461]](G) allele was statistically associated with the condition, with a per allele odds ratio of 1.5 (CI: 1.35–1.68, p = 6 × 10e?14).{{PMID|21532571}}

{{PMID Auto
|PMID=22714896
|Title=Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}