{{Rsnum
|rsid=4675690
|Chromosome=2
|position=207643083
|Orientation=plus
|GMAF=0.483
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 33.8 | 53.8 | 12.3
| HCB | 8.9 | 55.6 | 35.6
| JPT | 11.4 | 34.1 | 54.5
| YRI | 30.2 | 36.5 | 33.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 8.9 | 55.6 | 35.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4675690]] is in close proximity to [[CREB1]], and adjacent to [[LOC151194]].

[http://genes2brains2mentalhealth.wordpress.com/2008/05/14/rs4675690-c-allele-steers-my-left-insula-away-from-angry-old-farts/ g2b2mh blog] {{PMID|18678793|OA=1
}} individuals with the TT genotype at rs4675690 (C/T) showed less disgust, but not happiness, desire or fear.

{{PMID|17548750}} T allele associated with increased chance of [[suicide]] (OR = 2.3, 95% CI 1.3-2.9, TT homozygotes vs CC homozygotes?) during the first 30 days (p > 0.05 after the first month) of [[citalopram]] treatment, in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.
*[[rs2709376]](C),[[rs2253206]](A),[[rs7569963]](A),[[rs7594560]](T),[[rs4675690]](C) - common haplotype, reduced chance of suicide in males, p = 0.004
*[[rs2709376]](C),[[rs2253206]](A),[[rs7569963]](G),[[rs7594560]](T),[[rs4675690]](T) - increased chance of suicide in males, p = 0.009

{{PMID|17300755}} strongly associated with anger expression in male MDD patients

{{PharmGKB
|RSID=rs4675690
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17548750
|Annotation=In a nested case-control study derived from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study this SNP in the CREB1 gene was associated with treatment-emergent suicidality among men with depression.
|Drugs=citalopram
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162263535
}}

{{PMID Auto
|PMID=21807415
|Title=Early influence of the rs4675690 on the neural substrates of sadness
}}

{{PMID Auto
|PMID=22293360
|Title=Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population
}}

{{PMID|20643483}} A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4675690
|overall_frequency_n=69
|overall_frequency_d=126
|overall_frequency=0.547619
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=61
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22574704
|Title=CREB1 modulates the influence of childhood sexual abuse on adult's anger traits.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}