{{Rsnum
|rsid=4678
|Gene=VARS2
|Chromosome=6
|position=30926164
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.112
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
|Gene_s=VARS2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 66.7 | 29.7 | 3.6
| HCB | 88.3 | 11.7 | 0.0
| JPT | 98.2 | 1.8 | 0.0
| YRI | 78.9 | 19.7 | 1.4
| ASW | 75.4 | 24.6 | 0.0
| CHB | 88.3 | 11.7 | 0.0
| CHD | 88.9 | 11.1 | 0.0
| GIH | 86.1 | 12.9 | 1.0
| LWK | 65.1 | 32.1 | 2.8
| MEX | 82.8 | 17.2 | 0.0
| MKK | 80.1 | 17.9 | 1.9
| TSI | 66.7 | 30.4 | 2.9
| HapMapRevision=28
}}[[rs4678]] is a SNP representing an Arg/Gln variation in the [[VARS2L]] gene.

A study of 855 [[rheumatoid arthritis]] patients concluded that [[rs4678]] was one of only two SNPs representing an additional susceptibility gene - in addition to HLA-DRB1 - within the MHC region.{{PMID|19116923}}

There is some inconsistency in this SNP. The reference assembly considers it a A/G while RefSNP calls it a C/T. 

{{PMID Auto
|PMID=18204098
|Title=Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
}}

{{GET Evidence
|gene=VARS2
|aa_change=Arg1049Gln
|aa_change_short=R1049Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4678
|overall_frequency_n=1241
|overall_frequency_d=7516
|overall_frequency=0.165114
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.022
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}