{{Rsnum
|rsid=4680
|Gene=COMT
|Chromosome=22
|position=19963748
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3903
|Gene_s=COMT,MIR4761
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=warrior vs worrier
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 46.0 | 29.2
| HCB | 10.2 | 37.2 | 52.6
| JPT | 6.2 | 45.5 | 48.2
| YRI | 10.2 | 42.2 | 47.6
| ASW | 12.3 | 29.8 | 57.9
| CHB | 10.2 | 37.2 | 52.6
| CHD | 4.6 | 43.5 | 51.9
| GIH | 21.8 | 42.6 | 35.6
| LWK | 8.3 | 42.2 | 49.5
| MEX | 13.8 | 44.8 | 41.4
| MKK | 8.4 | 37.4 | 54.2
| TSI | 19.6 | 51.0 | 29.4
| HapMapRevision=28
}}
[[rs4680]] (Val158Met) is a well studied SNP in the [[COMT]] gene. [http://blog.23andme.com/2009/07/31/dna-variation-may-help-us-break-free-from-our-routines/ 23andMe blog] summarizes them as
*[[rs4680]](A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions
*[[rs4680]](G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions

Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at {{PMID|17008817}}) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compared with those with the Met substitution. Val158 alleles may be associated with an advantage in the processing of aversive stimuli (warrior strategy), while Met158 alleles may be associated with an advantage in memory and attention tasks (worrier strategy). Under conditions of increased dopamine release (eg, stress), individuals with Val158 alleles may have improved dopaminergic transmission and better performance, while individuals with Met158 alleles may have less efficient neurotransmission and worse performance. Some evidence suggests that Val158 alleles are associated with schizophrenia, while Met158 alleles are associated with anxiety.

Specific studies include:

[[rs4680]], a functional Val/Met polymorphism, showed modest association with Irish familial [[schizophrenia]]. Haplotype A-G-A for SNPs [[rs737865]]-[[rs4680]]-[[rs165599]] was preferentially transmitted to the affected subjects.

A study of 400 individuals reported that an increase in plasma total homocysteine (tHcy) of 10.4% (CI: 0.01-0.21, p=0.03) for associated with [[rs4680]](A;A) homozygotes compared with [[rs4680]](G;G) subjects. The (A;A) genotype was also more common, but statistically not that significantly, in [[venous thrombosis]] patients (OR 1.61, CI: 0.97-2.65], p=0.06) compared to control subjects.{{PMID|18064318}}

And from {{PMID|15866551}}:  
"Adolescent cannabis use was associated with increased risk of schizophreniform disorder in adulthood among Val/Val (i.e. [[rs4680(G;G)]]) individuals (OR = 10.9, 95% CI: 2.2â€“54.1) and, to a lesser extent, among Met/Val individuals ([[rs4680(A;G)]]); OR = 2.5, 95% CI: .78 â€“ 8.2), but not among Met/Met ([[rs4680(A;A)]]) individuals (OR = 1.1, 95% CI: .21â€“5.4)."

Also potentially associated with [[schizophrenia]]

As part of a haplotype with [[rs4633]], the (G) allele is also associated with [[endometrial cancer]]

In a study of 2 populations of [[breast cancer]] patients (2,000+ patients), increased risk was associated with [[rs4680]](G;G) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.{{PMID|18194538|OA=1
}} 

[http://blog.23andme.com/2008/08/10/snpwatch-genetic-variant-may-increase-risk-for-anxiety-disorders/ 23andMe blog] The A version of rs4680 appears to boost working memory and cognitive function compared to G â€” but it also hampers emotional control.

{{PMID|18704099|OA=1
}} A study of 330 cocaine-dependent individuals, all of African descent, concluded that there was a slight (odds ratio 1.44, CI: 1.12-1.86, p = 0.014) association between the [[rs4680]](A) allele, in other words the Met encoding allele, and [[cocaine dependence]].

{{PMID|18989660}} A study of the antidepressant [[paroxetine]] found better response in Met/Met homozygotes, worse effects in Val/Val homozygotes and intermediate effects in heterozygotes. The effect became significant at the third week of treatment. [[Paroxetine]] daily dose was proportional to baseline severity, but did not influence outcome.

[http://genes2brains2mentalhealth.wordpress.com/2008/09/24/michael-frank-probes-neurogenetic-basis-of-oops/ g2b2mh] (A;A) subjects deploy more attentional focus when they realize they have made an error.

A meta-analysis of neuroimaging studies found a significant association between the COMT genotype and prefrontal activation; strong and opposing effects were found for executive cognition paradigms (favoring Met allele carriers) and emotional paradigms (favoring Val).{{PMID|19417742}}

{{PMID|19071221|OA=1
}} gray matter volume and interacts with [[rs2097603]] related to extracellular dopamine

{{PMID|19207030}} [[rs6275]]/DRD2 and [[rs4680]]/COMT useful in predicting disease risk among [[schizophrenia]] patients

{{PMID|19037200}} [[rs4680]](G;G) carriers deprived of sleep respond quite well to 2x 100mg [[modafinil]] in terms of improved vigor and well-being, and maintained baseline performance with respect to executive functioning, whereas [[rs4680]](A;A) individuals barely responded to the drug at all.

{{PMID|16878403}} Met158 allele carriers had "a more focused response...during a working memory task." "The met158 allele seems to be beneficial during the performance of working memory and attention-related tasks, whereas the val158 allele appears to be advantageous during the processing of aversive emotional stimuli."

{{PMID|15673663}} "Increased limbic and prefrontal activation elicited by unpleasant stimuli in subjects with more met158 alleles might contribute to the observed lower emotional resilience against negative mood states."

{{PMID|12595695}} In response to pain Met/Met allele carriers showed greater "sensory and affective ratings of pain and a more negative internal affective state. Opposite effects were observed in val158 homozygotes. The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli."

{{PMID|20509070}} Reports that ease of entering [[hypnosis]] correlates with number of [[rs4680]](G) alleles.

see [[gs226]] for a report related to impulsiveness

{{omim
|desc=CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM
|id=116790
|quiet=1
|rsnum=4680
|variant=0001
}}

{{ neighbor
| rsid = 4818
| distance = 64
}}

{{ neighbor
| rsid = 17849308
| distance = 1
}}
{{PMID Auto
|PMID=19367610
|Title=Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients
}}
{{PMID Auto
|PMID=19369177
|Title=Association of the 3' Region of COMT with Schizophrenia in Taiwan
}}

{{PMID Auto
|PMID=19417742
|Title=Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
}}
{{PMID Auto
|PMID=19290789
|Title=Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
}}

{{PMID Auto
|PMID=19077118
|Title=Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
}}

{{omim
|id=104300
|desc=ALZHEIMER DISEASE; AD
|rsnum=4680
}}
{{PMID Auto
|PMID=19474754
|Title=Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1
}}

http://www.jneurosci.org/cgi/content/abstract/30/1/64 and [http://genes2brains2mind2me.com/2010/01/07/thousands-of-genes-together-with-thousands-of-resting-state-nodes-actually-makes-the-genes-to-cognition-problem-less-complex/ blog] discussion of data about rs4680 thinking about nothing in an fmri.

{{PMID Auto
|PMID=19915868
|Title=Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines
}}
{{PMID Auto
|PMID=19946713
|Title=Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant
}}

{{PharmGKB
|RSID=rs4680
|Name_s=
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19207030
|Annotation=This variant (rs4680/COMT) along with rs6275/DRD2 are associated with risk for schizophrenia in a study consisting of 254 patients and 225 controls of southern indian origin.
|Drugs=
|Drug Classes=
|Diseases=Psychotic Disorders; Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162630417
}}

{{PMID Auto
|PMID=20071037
|Title=Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder
}}
{{PMID Auto
|PMID=20070134
|Title=Association between COMT, [[PTSD]], and increased smoking following hurricane exposure in an epidemiologic sample
|OA=1
}}

{{PMID Auto
|PMID=19690620
|Title=Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=20150638
|Title=Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women
|OA=1
}}

{{PMID Auto
|PMID=20431430
|Title=The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness
}}
{{PMID Auto
|PMID=20488458
|Title=Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: New data and meta-analysis
}}
{{PMID Auto
|PMID=20934310
|Title=HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association
}}

{{PharmGKB
|RSID=rs4680
|Name_s=COMT:Val108Met
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/comt/variant.jsp
|Annotation=This variant is responsible for low (Met) and high (Val) activity alleles that have been studied in relation to schizophrenia and other psychiatric/neurological disorders and in relation to breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms; Schizophrenia
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145211
}}

{{PharmGKB
|RSID=rs4680
|Name_s=COMP: Val158Met
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:17156920
|Annotation=In an study at 207 patients treated with morphine, carriers of COMT Val/Val and Val/Met genotype required 63% and 23%, respectively, higher morphine dose compared to carriers of Met/Met genotype (p=0.02).
|Drugs=morphine
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA161748325
}}

{{PharmGKB
|RSID=rs4680
|Name_s=COMT: Val158Met
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19365560
|Annotation=The minor allele A of this 472G>A variant produces a valine to methionine substitution, resulting in a less thermostable COMT enzyme that exhibits a 3-fold reduction in activity.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164944057
}}

{{PharmGKB
|RSID=rs4680
|Name_s=COMT: Val158Met
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:15537663
|Annotation=On the basis of subjects' pain responsiveness, haplotypes involving rs6269 (A/G), rs4633 (C/T), rs4818 (C/G), and rs4680 (G/A) were designated as low (low pain sensitivity (LPS) haplotype; GCGG), average (average pain sensitivity (APS) haplotype; ATCA), or high (high pain sensitivity (HPS) haplotype; ACCG) pain sensitive.
|Drugs=
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA164944062
}}
{{PMID Auto
|PMID=20570835
|Title=No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
}}
{{PMID Auto
|PMID=21084795
|Title=Acute Intravenous Synaptamine Complex Variant KB220™ "Normalizes" Neurological Dysregulation in Patients During Protracted Abstinence From Alcohol and Opiates as Observed Using Quantitative Electroencephalographic and Genetic Analysis for Reward Polymorphisms: Part 1, Pilot Study with 2 Case Reports
}}
{{PMID Auto
|PMID=21092186
|Title=Polymorphisms in genes involved in the estrogen pathway and mammographic density
|OA=1
}}
{{PMID Auto
|PMID=21120493
|Title=Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients
}}
{{PMID Auto
|PMID=21130573
|Title=COMT moderates the relation of daily maladaptive coping and pain in [[fibromyalgia]]
|OA=1
}}
{{PMID Auto
|PMID=21191472
|Title=Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers
|OA=1
}}

{{PMID Auto
|PMID=21300128
|Title=COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa
}}

{{PMID Auto
|PMID=10490706
|Title=Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype
}}

{{PMID Auto
|PMID=17949513
|Title=Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
}}

{{PMID Auto
|PMID=21310591
|Title=Interaction between COMT haplotypes and cannabis in schizophrenia: A case-only study in two samples from Spain
}}

{{PMID Auto
|PMID=21449006
|Title=Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to transcranial magnetic stimulation
}}

{{PMID Auto
|PMID=21567099
|Title=Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer
}}

{{PMID Auto
|PMID=21570824
|Title=Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids
}}

{{PMID Auto
|PMID=21595525
|Title=Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder
}}

{{PMID Auto
|PMID=21884617
|Title=Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults
|OA=1
}}

{{PMID Auto
|PMID=21934638
|Title=A COMT gene haplotype associated with methamphetamine abuse
}}

{{PMID Auto
|PMID=21940152
|Title=The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
}}

{{PMID Auto
|PMID=22067551
|Title=When control fails: Influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task
}}

{{PMID Auto
|PMID=21947654
|Title=Cannabis, COMT and psychotic experiences
}}

{{PMID Auto
|PMID=22222175
|Title=COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes
}}

{{PMID Auto
|PMID=22337560
|Title=The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation
}}

{{PMID Auto
|PMID=22417933
|Title=Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder
}}

{{PMID Auto
|PMID=22451510
|Title=Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD
}}

{{PMID Auto
|PMID=22479488
|Title=No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women
|OA=1
}}

{{PMID Auto
|PMID=22475780
|Title=Association Between Val158Met Functional Polymorphism in the COMT Gene and Risk of Preeclampsia in a Chinese Population
}}

{{PMID Auto
|PMID=22528689
|Title=Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene
}}

{{PMID Auto
|PMID=22208661
|Title=A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence : a case control study
|OA=1
}}

{{PMID Auto
|PMID=22178088
|Title=Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome
|OA=1
}}

{{PMID Auto
|PMID=22658813
|Title=Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non-Small-Cell Lung Cancer Risk in Chinese Nonsmokers
}}

{{ClinVar
|rsid=4680
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=19951271
|CHROM=22
|GMAF=0.3892
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05037800000015051f110101
|GENEINFO=COMT:1312; MIR4761:100616414
|GENE_NAME=COMT; MIR4761
|GENE_ID=1312; 100616414
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.19951271G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6097; 0.3903
|CLNACC=RCV000019156.2
|CLNDBN=CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=116790.0001
|COMMON=1
|Disease=CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM
}}

{{PMID Auto
|PMID=12802784
|Title=A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
|OA=1
}}

{{PMID Auto
|PMID=15098000
|Title=COMT haplotypes suggest P2 promoter region relevance for schizophrenia.
}}

{{PMID Auto
|PMID=15124004
|Title=Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.
}}

{{PMID Auto
|PMID=15290009
|Title=Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.
}}

{{PMID Auto
|PMID=15457404
|Title=Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.
|OA=1
}}

{{PMID Auto
|PMID=15505638
|Title=Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.
}}

{{PMID Auto
|PMID=15931594
|Title=An entropy-based statistic for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=15956988
|Title=COMT polymorphisms and anxiety-related personality traits.
}}

{{PMID Auto
|PMID=16027741
|Title=Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
}}

{{PMID Auto
|PMID=16232322
|Title=COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=16380905
|Title=Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
|OA=1
}}

{{PMID Auto
|PMID=16380908
|Title=Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
|OA=1
}}

{{PMID Auto
|PMID=16395295
|Title=Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.
}}

{{PMID Auto
|PMID=16412218
|Title=Multilocus analysis of SNP and metabolic data within a given pathway.
|OA=1
}}

{{PMID Auto
|PMID=16453988
|Title=Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.
}}

{{PMID Auto
|PMID=16483362
|Title=The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
|OA=1
}}

{{PMID Auto
|PMID=16574089
|Title=PCR screening for 22q11.2 microdeletion: development of a new cost-effective diagnostic tool.
}}

{{PMID Auto
|PMID=16786032
|Title=Impact of complex genetic variation in COMT on human brain function.
}}

{{PMID Auto
|PMID=16816420
|Title=Nonlinear tests for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=16816940
|Title=Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.
}}

{{PMID Auto
|PMID=16837108
|Title=Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
}}

{{PMID Auto
|PMID=16848906
|Title=Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.
|OA=1
}}

{{PMID Auto
|PMID=17006672
|Title=Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.
}}

{{PMID Auto
|PMID=17116718
|Title=Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=17299513
|Title=Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.
}}

{{PMID Auto
|PMID=17363961
|Title=Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
}}

{{PMID Auto
|PMID=17427186
|Title=Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
}}

{{PMID Auto
|PMID=17429315
|Title=Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.
}}

{{PMID Auto
|PMID=17442488
|Title=An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population.
}}

{{PMID Auto
|PMID=17466074
|Title=Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=17482701
|Title=No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
}}

{{PMID Auto
|PMID=17483451
|Title=Gene-gene interaction associated with neural reward sensitivity.
|OA=1
}}

{{PMID Auto
|PMID=17504246
|Title=Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.
}}

{{PMID Auto
|PMID=17604122
|Title=A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population.
}}

{{PMID Auto
|PMID=17630406
|Title=Dopamine genes and schizophrenia: case closed or evidence pending?
|OA=1
}}

{{PMID Auto
|PMID=17636223
|Title=Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.
}}

{{PMID Auto
|PMID=17707347
|Title=Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.
|OA=1
}}

{{PMID Auto
|PMID=17961261
|Title=Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
|OA=1
}}

{{PMID Auto
|PMID=17994190
|Title=Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.
}}

{{PMID Auto
|PMID=18081002
|Title=Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.
}}

{{PMID Auto
|PMID=18180394
|Title=Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.
|OA=1
}}

{{PMID Auto
|PMID=18196244
|Title=Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
}}

{{PMID Auto
|PMID=18213617
|Title=Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.
}}

{{PMID Auto
|PMID=18235427
|Title=Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.
}}

{{PMID Auto
|PMID=18324659
|Title=COMT polymorphisms affecting protein expression are risk factors for endometrial cancer.
}}

{{PMID Auto
|PMID=18340529
|Title=A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18351593
|Title=DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.
}}

{{PMID Auto
|PMID=18384078
|Title=Association study of candidate variants of COMT with neuroticism, anxiety and depression.
}}

{{PMID Auto
|PMID=18389087
|Title=Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.
|OA=1
}}

{{PMID Auto
|PMID=18408230
|Title=Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
|OA=1
}}

{{PMID Auto
|PMID=18436194
|Title=Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18444252
|Title=Neurotransmission and bipolar disorder: a systematic family-based association study.
|OA=1
}}

{{PMID Auto
|PMID=18466599
|Title=Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels.
|OA=1
}}

{{PMID Auto
|PMID=18466879
|Title=Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.
|OA=1
}}

{{PMID Auto
|PMID=18486967
|Title=A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A).
|OA=1
}}

{{PMID Auto
|PMID=18562342
|Title=Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18592033
|Title=Sex steroid-related candidate genes in psychiatric disorders.
|OA=1
}}

{{PMID Auto
|PMID=18628428
|Title=Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=18698234
|Title=The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=18755576
|Title=Effect of COMT val158met genotype on cognition and personality.
}}

{{PMID Auto
|PMID=18787887
|Title=Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
|OA=1
}}

{{PMID Auto
|PMID=18802928
|Title=Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18820009
|Title=Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers.
}}

{{PMID Auto
|PMID=18929622
|Title=Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.
}}

{{PMID Auto
|PMID=18937309
|Title=Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study.
|OA=1
}}

{{PMID Auto
|PMID=18988738
|Title=MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.
|OA=1
}}

{{PMID Auto
|PMID=19074205
|Title=Drinking green tea modestly reduces breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19094200
|Title=Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.
|OA=1
}}

{{PMID Auto
|PMID=19094875
|Title=[Effect of polymorphisms of the cathecol-O-methyltransferase on schizophrenia risk in a Spanish population].
}}

{{PMID Auto
|PMID=19127255
|Title=Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=19174490
|Title=Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.
|OA=1
}}

{{PMID Auto
|PMID=19197363
|Title=A genome-wide investigation of SNPs and CNVs in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19258022
|Title=Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
|OA=1
}}

{{PMID Auto
|PMID=19287484
|Title=Clique-finding for heterogeneity and multidimensionality in biomarker epidemiology research: the CHAMBER algorithm.
|OA=1
}}

{{PMID Auto
|PMID=19329282
|Title=Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
}}

{{PMID Auto
|PMID=19359258
|Title=Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19520435
|Title=Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism.
}}

{{PMID Auto
|PMID=19545856
|Title=Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.
|OA=1
}}

{{PMID Auto
|PMID=19578924
|Title=The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.
}}

{{PMID Auto
|PMID=19582565
|Title=Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
}}

{{PMID Auto
|PMID=19584770
|Title=Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events.
}}

{{PMID Auto
|PMID=19647329
|Title=COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia.
}}

{{PMID Auto
|PMID=19664744
|Title=A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease.
|OA=1
}}

{{PMID Auto
|PMID=19693005
|Title=Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=19721400
|Title=Association between COMT gene and Chinese male schizophrenic patients with violent behavior.
}}

{{PMID Auto
|PMID=19852950
|Title=The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders.
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=19940176
|Title=Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
|OA=1
}}

{{PMID Auto
|PMID=20122740
|Title=Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.
}}

{{PMID Auto
|PMID=20148275
|Title=Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.
|OA=1
}}

{{PMID Auto
|PMID=20179754
|Title=Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.
|OA=1
}}

{{PMID Auto
|PMID=20191112
|Title=The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
|OA=1
}}

{{PMID Auto
|PMID=20205808
|Title=Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.
|OA=1
}}

{{PMID Auto
|PMID=20483479
|Title=Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.
}}

{{PMID Auto
|PMID=20531207
|Title=The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=20627703
|Title=The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
}}

{{PMID Auto
|PMID=20667552
|Title=Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
}}

{{PMID Auto
|PMID=20728009
|Title=Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism.
}}

{{PMID Auto
|PMID=20863768
|Title=Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
}}

{{PMID Auto
|PMID=20878621
|Title=Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
}}

{{PMID Auto
|PMID=20979431
|Title=Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China.
}}

{{PMID Auto
|PMID=21059181
|Title=Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome.
}}

{{PMID Auto
|PMID=21106664
|Title=Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women.
|OA=1
}}

{{PMID Auto
|PMID=21144097
|Title=The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract.
}}

{{PMID Auto
|PMID=21162693
|Title=Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
|OA=1
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21215384
|Title=Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex.
}}

{{PMID Auto
|PMID=21216270
|Title=Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.
}}

{{PMID Auto
|PMID=21300759
|Title=EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.
}}

{{PMID Auto
|PMID=21304959
|Title=Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
|OA=1
}}

{{PMID Auto
|PMID=21330274
|Title=Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials.
|OA=1
}}

{{PMID Auto
|PMID=21355050
|Title=A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
|OA=1
}}

{{PMID Auto
|PMID=21356266
|Title=Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes.
|OA=1
}}

{{PMID Auto
|PMID=21423693
|Title=Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.
|OA=1
}}

{{PMID Auto
|PMID=21445667
|Title=Variation in genes involved in dopamine clearance influence the startle response in older adults.
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{PMID Auto
|PMID=21486391
|Title=The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide.
}}

{{PMID Auto
|PMID=21495799
|Title=COMT polymorphism and the risk of endometriosis-related infertility.
}}

{{PMID Auto
|PMID=21508242
|Title=Dopaminergic genes predict individual differences in susceptibility to confirmation bias.
|OA=1
}}

{{PMID Auto
|PMID=21600957
|Title=COMT and age at onset in mood disorders: a replication and extension study.
}}

{{PMID Auto
|PMID=21609749
|Title=Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.
}}

{{PMID Auto
|PMID=21656904
|Title=Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
|OA=1
}}

{{PMID Auto
|PMID=21776034
|Title=Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake.
}}

{{PMID Auto
|PMID=21895373
|Title=Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.
}}

{{PMID Auto
|PMID=21999147
|Title=Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia.
}}

{{PMID Auto
|PMID=22024485
|Title=Genetic associations with performance on a behavioral measure of distress intolerance.
|OA=1
}}

{{PMID Auto
|PMID=22259185
|Title=Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity.
}}

{{PMID Auto
|PMID=22293393
|Title=Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity.
}}

{{PMID Auto
|PMID=22349272
|Title=Age modulates the effect of COMT genotype on delay discounting behavior.
|OA=1
}}

{{PMID Auto
|PMID=22366815
|Title=Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.
}}

{{PMID Auto
|PMID=22466345
|Title=Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.
|OA=1
}}

{{PMID Auto
|PMID=22487365
|Title=C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate.
}}

{{PMID Auto
|PMID=22530780
|Title=Impact of five SNPs in dopamine-related genes on executive function.
}}

{{PMID Auto
|PMID=22963606
|Title=No association of catechol-o-methyltransferase polymorphisms with schizophrenia in the han chinese population
|OA=1
}}

{{PMID Auto
|PMID=22615781
|Title=Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|OA=1
}}

{{PMID Auto
|PMID=22978509
|Title=Convergence of Genome-Wide Association and Candidate Gene Studies for Alcoholism
|OA=1
}}

{{PMID Auto
|PMID=22707271
|Title=The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion
}}

{{GET Evidence
|gene=COMT
|aa_change=Val158Met
|aa_change_short=V158M
|impact=benign
|qualified_impact=Insufficiently evaluated benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4680
|overall_frequency_n=4823
|overall_frequency_d=10756
|overall_frequency=0.448401
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|in_omim=Y
|nblosum100=0
|autoscore=2
|webscore=N
|summary_short=A codominant allele affecting COMT enzyme activity, considered a benign functional polymorphism.
}}

{{PMID Auto
|PMID=23141115
|Title=The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder
}}

[[Breast Cancer Risk Modifiers]]

{{PMID Auto
|PMID=22790479
|Title=Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese
}}

{{PMID Auto
|PMID=22612913
|Title=Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study
|OA=1
}}

{{PMID Auto
|PMID=23269216
|Title=Association between the COMT gene and rumination in a Hungarian sample
}}

{{PMID Auto
|PMID=23278923
|Title=The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation
|OA=1
}}

{{PMID Auto
|PMID=23288874
|Title=Lack of Association of a Functional Catechol-O-Methyltransferase Gene Polymorphism With Risk of Tobacco Smoking: Results From a Multicenter Case-Control Study
}}

{{PMID Auto
|PMID=23370603
|Title=Catechol-O-Methyltransferase and Cytochrome P-450 1B1 Polymorphisms and Endometrial Cancer Risk: A Meta-analysis
}}

{{PMID Auto
|PMID=23369671
|Title=Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study
|OA=1
}}

{{PMID Auto
|PMID=23440431
|Title=Association of the COMT Met158 allele with trait impulsivity in healthy young adults
}}

{{PMID Auto
|PMID=23515273
|Title=Playing nice: a multi-methodological study on the effects of social conformity on memory
|OA=1
}}

{{PMID Auto
|PMID=23715639
|Title=The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth
}}

{{PMID Auto
|PMID=23728717
|Title=Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample
}}

{{PMID Auto
|PMID=23785672
|Title=Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans
|OA=1
}}

{{PMID Auto
|PMID=23798967
|Title=No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
|OA=1
}}

{{PMID Auto
|PMID=23353103
|Title=COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study
}}

{{PMID Auto
|PMID=23840506
|Title=Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
|OA=1
}}

{{PMID Auto
|PMID=23880798
|Title=No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women
}}

{{PMID Auto
|PMID=23928748
|Title=Impact of COMT genotype on serotonin-1A receptor binding investigated with PET
}}

{{PMID Auto
|PMID=23941313
|Title=Influence of a Dopamine Pathway Additive Genetic Efficacy Score on Smoking Cessation: Results from Two Randomized Clinical Trials of Bupropion
}}

{{PMID Auto
|PMID=24167357
|Title=COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery
|OA=1
}}

{{PMID Auto
|PMID=24320736
|Title=Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study
}}

{{PMID Auto
|PMID=24382678
|Title=Association between maternal COMT gene polymorphisms and fetal neural tube defects risk in a Chinese population
}}

{{PMID Auto
|PMID=24399714
|Title=BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample
}}

{{PMID Auto
|PMID=24407958
|Title=Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
}}

{{PMID Auto
|PMID=24448899
|Title=Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype
}}

{{PMID Auto
|PMID=24499375
|Title=Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
}}

{{PMID Auto
|PMID=23706899
|Title=Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder
}}

{{PMID Auto
|PMID=24575113
|Title=Association between the COMTVal158Met Genotype and Alzheimer's Disease in the Han Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=22021659
|Title=Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=22683321
|Title=Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology.
}}

{{PMID Auto
|PMID=22713126
|Title=COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.
}}

{{PMID Auto
|PMID=22718527
|Title=The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.
}}

{{PMID Auto
|PMID=22722321
|Title=Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.
}}

{{PMID Auto
|PMID=22763378
|Title=Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=22784685
|Title=The COMT Met158 allele and violence in schizophrenia: a meta-analysis.
}}

{{PMID Auto
|PMID=22841130
|Title=Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes.
}}

{{PMID Auto
|PMID=22890010
|Title=Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
}}

{{PMID Auto
|PMID=22890094
|Title=Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.
}}

{{PMID Auto
|PMID=22900954
|Title=COMT val158met predicts reward responsiveness in humans.
}}

{{PMID Auto
|PMID=22901597
|Title=Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.
}}

{{PMID Auto
|PMID=23000097
|Title=Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.
}}

{{PMID Auto
|PMID=23008195
|Title=Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression.
}}

{{PMID Auto
|PMID=23069674
|Title=No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias.
}}

{{PMID Auto
|PMID=23133420
|Title=Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
|OA=1
}}

{{PMID Auto
|PMID=23178897
|Title=The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
|OA=1
}}

{{PMID Auto
|PMID=23219927
|Title=Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.
}}

{{PMID Auto
|PMID=23261162
|Title=DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task.
}}

{{PMID Auto
|PMID=23302985
|Title=The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia.
}}

{{PMID Auto
|PMID=23351565
|Title=Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.
}}

{{PMID Auto
|PMID=23408064
|Title=The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.
|OA=1
}}

{{PMID Auto
|PMID=23421762
|Title=COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.
}}

{{PMID Auto
|PMID=23618651
|Title=Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder.
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=23773341
|Title=An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans.
}}

{{PMID Auto
|PMID=23774690
|Title=Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.
}}

{{PMID Auto
|PMID=23818048
|Title=Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults.
}}

{{PMID Auto
|PMID=24593143
|Title=Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children
|OA=1
}}

{{PMID Auto
|PMID=24763183
|Title=Catechol-O-methyltransferase Val158-Met polymorphism and a response of hyperactive-impulsive symptoms to methylphenidate: A replication study from South Korea
}}

{{PMID Auto
|PMID=24777039
|Title=A Multicenter Case-Control Study on Screening of Single Nucleotide Polymorphisms in Estrogen-Metabolizing Enzymes and Susceptibility to Uterine Leiomyoma in Han Chinese
}}

{{PMID Auto
|PMID=24819480
|Title=COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24853458
|Title=Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects
}}

{{PMID Auto
|PMID=23598060
|Title=Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
}}

{{PMID Auto
|PMID=25013436
|Title=The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis
}}

{{PMID Auto
|PMID=25029900
|Title=Interactive effects of the COMT gene and training on individual differences in supervisory control of unmanned vehicles
}}

{{PMID Auto
|PMID=25038551
|Title=Dopamine system genes are associated with orienting bias among healthy individuals
}}

{{PMID Auto
|PMID=25063767
|Title=Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD
}}

{{PMID Auto
|PMID=25161818
|Title=The influence of COMT Val(158)Met genotype on the character dimension cooperativeness in healthy females
}}

{{PMID Auto
|PMID=24274352
|Title=Green tea consumption and breast cancer risk in Japanese women: a case-control study
}}

{{PMID Auto
|PMID=25218601
|Title=Epistasis Between Polymorphisms in COMT, ESR1, and GCH1 Influences COMT Enzyme Activity and Pain
}}

{{PMID Auto
|PMID=24225542
|Title=Association of COMT val158met and DRD2 G&gt;T genetic polymorphisms with individual differences in motor learning and performance in female young adults
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}