{{Rsnum
|rsid=4684677
|Gene=GHRL
|Chromosome=3
|position=10286769
|Orientation=plus
|GMAF=0.0652
|Gene_s=GHRL,GHRLOS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 1.5 | 18.5 | 80.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 2.3 | 97.7
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{omim
|id=605353
|desc=GHRELIN; GHRL
|rsnum=4684677
}}

{{PMID Auto
|PMID=20010782
|Title=Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease
}}

{{omim
|id=605353
|rsnum=4684677
|variant=0003
}}

{{PMID Auto
|PMID=22005651
|Title=Genetic association between ghrelin polymorphisms and Alzheimer's disease in a Japanese population
}}

{{ClinVar
|rsid=4684677
|Reversed=0
|FwdREF=T
|FwdALT=A
|REF=T
|ALT=A
|RSPOS=10328453
|CHROM=3
|GMAF=0.0655
|dbSNPBuildID=111
|SSR=0
|SAO=1
|VP=0x05036800000015051f110101
|GENEINFO=GHRLOS:100126793; GHRL:51738
|GENE_NAME=GHRLOS; GHRL
|GENE_ID=100126793; 51738
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.10328453T>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=605353.0003
|CLNSIG=255
|CLNCUI=C0028754
|CLNDBN=Obesity
|Disease=Obesity
|CLNACC=RCV000023422.1
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9348; 0.0652
|CLNDSDB=MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C0028754:601665:71529:414916001
|COMMON=1
}}

{{PMID Auto
|PMID=16204371
|Title=Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish.
}}

{{PMID Auto
|PMID=17389697
|Title=Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
}}

{{PMID Auto
|PMID=18239581
|Title=Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles.
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19165163
|Title=Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.
}}

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=20586762
|Title=Genetic variation of the ghrelin signaling system in females with severe alcohol dependence.
}}

{{PMID Auto
|PMID=21448464
|Title=The ghrelin signalling system is involved in the consumption of sweets.
|OA=1
}}

{{GET Evidence
|gene=GHRL
|aa_change=Gln90Leu
|aa_change_short=Q90L
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4684677
|overall_frequency_n=5
|overall_frequency_d=128
|overall_frequency=0.0390625
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=!
|qualitycomment_in_silico=Y
|qualityscore_case_control=3
|qualitycomment_case_control=Y
|in_omim=Y
|pph2_score=1.0
|nblosum100=5
|autoscore=4
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=Initially thought to be associated with obesity, but follow-up comparisons found no enrichment in combined data. Polyphen 2 predicts a damaging effect.
}}

{{PMID Auto
|PMID=23251435
|Title=A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in Mice
|OA=1
}}

{{PMID Auto
|PMID=23084284
|Title=A possible association between panic disorder and a polymorphism in the preproghrelingene.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}