{{Rsnum
|rsid=4686484
|Gene=LPP
|Chromosome=3
|position=188400784
|Orientation=plus
|GMAF=0.3797
|Gene_s=LPP
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs4686484]] is a SNP in the [[LPP]] gene. The LPP protein is involved in cell motility and cell–cell adhesion, which is crucial to maintaining the barrier integrity of epithelial monolayers such as those in the small intestine.

A study of several populations eventually settled on [[rs4686484]] as the SNP most likely to be the functional variant at the heart of the haplotypes associated with altered risk for [[celiac disease]]. The rarer [[rs4686484]](G) allele is less common in patients than in healthy controls, and it is therefore thought to have a (slight) protective role, leading to reduced risk for the disorder.{{PMID|24334606|OA=1
}}